Metastatic infection caused by hypervirulent Klebsiella pneumonia and co-infection with Cryptococcus meningitis: A case report

Table 1 Resistance profiles and minimum inhibitory concentrations for Klebsiella pneumoniae from blood culture

Antibiotic	Drug sensitivity	MIC
Ampicillin	R	≥ 32
Cefazolin	S	≤ 4
Ceftazidime	S	≤ 1
Ceftriaxone	S	≤ 1
Cefepime	S	≤ 1
Aztreonam	S	≤ 1
Imipenem	S	≤ 1
Ertapenem	S	≤ 0.5
Amoxicillin/clavulanate	R	UD
Piperacillin/tazobactam	S	≤ 4
Ciprofloxacin	S	≤ 0.25
Levofloxacin	S	≤ 0.25
Tobramycin	S	≤ 1
Gentamicin	S	≤ 1
Amikacin	S	≤ 2
Cefotiam	S	UD
Cefotetan	S	≤ 4
Latamoxef	S	UD
Cefoperazone/sulbactam	S	≤ 4
Ampicillin/sulbactam	S	4
SMZCo	S	≤ 20
Macrodantin	I	64
Moxifloxacin	S	≤ 0.25
ESBL detection	Negative

Results from Sun Yat-Sen University Cancer Center. Reported day before admission to Medical Intensive Care Unit of The Third Affiliated Hospital of Sun Yat-Sen University. ESBL: Extended-spectrum β-lactamase; I: Intermediate; MIC: Minimum inhibitory concentration; R: Resistant; S: Sensitive; UD: Undetected; SMZCo: Compound sulfamethoxazole.

Table 2 Resistance profiles and minimum inhibitory concentrations for Klebsiella pneumoniae from cerebrospinal fluid culture

Antibiotics	Drug sensitivity	MIC
Ampicillin	R	16
Piperacillin	S	≤ 16
Cefazolin	S	≤ 8
Cefoxitin	S	≤ 8
Cefuroxime	S	≤ 4
Cefotaxime	S	≤ 2
Ceftazidime	S	≤ 1
Ceftriaxone	S	≤ 8
Cefepime	S	≤ 8
Aztreonam	S	≤ 8
Imipenem	S	≤ 1
Meropenem	S	≤ 1
Ertapenem	S	≤ 2
Amoxicillin/clavulanate	S	≤ 8/4
Piperacillin/tazobactam	S	≤ 16
Ticarcillin/clavulanate	S	≤ 16
Ciprofloxacin	S	≤ 1
Levofloxacin	S	≤ 2
Tobramycin	S	≤ 4
Gentamicin	S	≤ 4
Amikacin	S	≤ 8
Tetracycline	S	≤ 4
Trimethoprim/sulfanilamide	S	≤ 2/38
Cefotaxime/clavulanate	S	≤ 0.5
Ceftazidime/clavulanate	S	≤ 0.25

Results from the Third Affiliated Hospital of Sun Yat-Sen University. Report date: 1 d after death. MIC: Minimum inhibitory concentration; R: Resistant; S: Sensitive.

Table 3 Resistance profiles and minimum inhibitory concentrations for Klebsiella pneumoniae from sputum culture

Antibiotic	Drug sensitivity	MIC
Ampicillin	R	> 32
Cefazolin	S	2
Cefoxitin	S	≤ 2
Cefuroxime	S	4
Cefotaxime	S	≤ 0.5
Ceftazidime	S	≤ 1
Cefepime	S	≤ 1
Imipenem	S	≤ 0.5
Piperacillin/tazobactam	I	32

Results from the Third Affiliated Hospital of Sun Yat-Sen University. Report date: 3 d after death. MIC: Minimum inhibitory concentration; R: Resistant; S: Sensitive; I: Intermediate.