Shi YF, Wang YK, Wang YH, Liu H, Shi XH, Li XJ, Wu BQ. Metastatic infection caused by hypervirulent Klebsiella pneumonia and co-infection with Cryptococcus meningitis: A case report. World J Clin Cases 2019; 7(22): 3812-3820 [PMID: 31799309 DOI: 10.12998/wjcc.v7.i22.3812]
Corresponding Author of This Article
Ben-Quan Wu, PhD, Professor, Director, Medical Intensive Care Unit, Department of Respiratory and Critical Care Medicine, Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tian He Road, Guangzhou 510630, Guangdong Province, China. zswbq@163.com
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Case Report
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Shi YF, Wang YK, Wang YH, Liu H, Shi XH, Li XJ, Wu BQ. Metastatic infection caused by hypervirulent Klebsiella pneumonia and co-infection with Cryptococcus meningitis: A case report. World J Clin Cases 2019; 7(22): 3812-3820 [PMID: 31799309 DOI: 10.12998/wjcc.v7.i22.3812]
Yun-Feng Shi, Yu-Kai Wang, Yan-Hong Wang, Hui Liu, Xiao-Han Shi, Ben-Quan Wu, Medical Intensive Care Unit, Department of Respiratory and Critical Care Medicine, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China
Yun-Feng Shi, Yu-Kai Wang, Yan-Hong Wang, Hui Liu, Xiao-Han Shi, Ben-Quan Wu, Institute of Respiratory Diseases, Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China
Xiao-Jie Li, Department of Laboratory Medicine, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, China
Author contributions: Shi YF and Wu BQ analyzed the data, designed the report, and drafted the manuscript; Wang YK collected the data, reviewed the literature, and contributed to manuscript drafting; Wang YH and Liu H made contributions to collect the patient’s clinical data; Shi XH collected the data and revised the manuscript; Li XJ performed the microbiological analyses; Wu BQ was responsible for the revision of the manuscript for important content; All authors approved the final version.
Supported byScience and Technology Planning Project of Guangdong Province of China, No. 2017A020215177.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Ben-Quan Wu, PhD, Professor, Director, Medical Intensive Care Unit, Department of Respiratory and Critical Care Medicine, Third Affiliated Hospital of Sun Yat-Sen University, No. 600 Tian He Road, Guangzhou 510630, Guangdong Province, China. zswbq@163.com
Telephone: +86-20-85253479 Fax: +86-20-85252092
Received: May 17, 2019 Peer-review started: May 23, 2019 First decision: September 9, 2019 Revised: September 30, 2019 Accepted: October 15, 2019 Article in press: October 15, 2019 Published online: November 26, 2019 Processing time: 193 Days and 23.9 Hours
Core Tip
Core tip: Hypervirulent Klebsiella pneumoniae (hvKP) has emerged as a cause of metastatic infections in immunocompetent hosts and presents mainly as a monomicrobial infection. We present a rare case of metastatic infection caused by hvKP and co-infection with Cryptococcus neoformans meningitis. The patient received antibiotics that were sensitive to pathogens in time, and the infection was under control for 1 wk. However, his condition deteriorated rapidly because of metastatic purulent meningitis, and he died of spontaneous respiratory and cardiac arrest caused by cerebral hernia. This case highlights the risk of complications and polymicrobial co-infections in hvKP infected patients. Timely ventricle drainage is strongly recommended for polymicrobial co-infected meningitis.
