Systemic lupus erythematosus complicated by noncirrhotic portal hypertension: A case report and review of literature

Table 1 Characteristics and treatment of patients with systemic lupus erythematosus complicated by noncirrhotic portal hypertension based on a literature review

No.	Author	Yr	Age/sex	Interval between SLE and NCPH (yr)	Complicated by other diseases	Positive immunological markers	Hepatic dysfunction	Portal thrombosis	Hepatic histopathology	Treatment of SLE
1	Woolf et al[4]	1994	19/F	8	PAH	ANA, dsDNA, CIC, CH50	No	No	PF	GCs, CTX
2	Takahaski et al[5]	1995	26/M	5.5	ACL, AMI	ANA, dsDNA, ACL, CH50, IgG	Yes	No	PF	GCs
3	Sekiya et al[6]	1997	43/F	N/A	No	ANA, dsDNA, CH50, IgG	Yes	No	NRH	GCs
4	Nakajima et al[7]	1999	29/M	3	No	ANA, CH50	Yes	No	PF	GCs, AZA
5	Inagaki et al[8]	2000	38/M	12	No	LA, ACL, CH50	Yes	No	PF	GCs
6	Horita et al[9]	2002	40/F	14	No	ANA, dsDNA	No	No	NRH	GCs
7	Colmegna et al[10]	2005	39/F	8	PAH	ANA, dsDNA, ACL	No	No	NRH	GCs, CTX
8	Park et al[11]	2006	37/F	3	PAH	ANA, dsDNA, RNP, Smith	Yes	No	NRH	GCs, HCQ
9	Leung et al[12]	2007	37/F	0	ITP	ANA, dsDNA, ACL	Yes	No	NRH	GCs
10	Leung et al[13]	2009	54/F	14	No	N/A	Yes	No	NRH	GCs, AZA
11	Leung et al[13]	2009	56/F	18	No	N/A	No	No	NRH	GCs
12	Leung et al[13]	2009	56/F	5	No	N/A	Yes	No	NRH	GCs, AZA
13	Louwers et al[14]	2012	37/F	N/A	No	N/A	Yes	No	NRH	GCs, AZA
14	Guo et al[15]	2012	N/A	N/A	No	ANA, dsDNA, SSA, IgG	Yes	No	NRH	MTX
15	Guo et al[15]	2012	N/A	N/A	No	ANA ,ACL, SMA	No	No	NRH	AZA
16	Guo et al[15]	2012	N/A	N/A	Cryoglobulinemia	ANA, dsDNA, RNP, IgG	No	No	NRH	CTX
17	Guo et al[15]	2012	N/A	N/A	PIF	Smith, RNP, IgG	Yes	No	NRH	CTX
18	Guo et al[15]	2012	N/A	N/A	PAH, PTE	ANA, Smith	No	No	NRH	CTX
19	Zhang et al[16]	2017	35/F	2	PCP	ANA, ANUA	No	No	NRH, PF	GCs, CsA
20	Zhang et al[16]	2017	41/F	6	PCP	ANA, dsDNA, ANUA	No	No	NRH	GCs, MTX
21	Zhang et al[16]	2017	25/F	9.5	PCP	ANA, ACL, ANUA	No	No	N/A	GCs, MTX
22	Zhang et al[16]	2017	25/F	10	PCP	ANA, dsDNA, ACL, ANUA	Yes	No	N/A	GCs, MTX

PAH: Pulmonary arterial hypertension; NRH: Nodular regenerative hyperplasia; N/A: Not applicable; PIF: Pulmonary interstitial fibrosis; PTE: Pulmonary thromboembolism; PCP: Pancytopenia; PF: Portal fibrosis; ACL: Anti-cardiolipin; GCs: Glucocorticoids; CTX: Cyclophosphamide; AZA: Azathioprine; MTX: Methotrexate; HCQ: Hydroxychloroquine; CsA: Cyclosporine.