Paget’s disease of the nipple with occult ductal carcinoma in situ despite negative conventional imaging: A case report

doi:10.12998/wjcc.v14.i16.120049

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World Journal of Clinical Cases

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2307-8960

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Cases. Jun 6, 2026; 14(16): 120049
Published online Jun 6, 2026. doi: 10.12998/wjcc.v14.i16.120049

Table 1 Clinical timeline

Time	Clinical events
November 2023	Skin biopsy: Chronic inflammation with granulation tissue
October 2024	Mammography: Grouped calcifications without significant changes compared to previous mammography in a local hospital
	Breast ultrasonography: Cutaneous changes that raise suspicion for Paget’s disease
	Repeat skin biopsy: Confirmed Paget’s disease. Estrogen receptor equivocal staining, progesterone receptor-negative, HER2-positive (3+ 90% of cells)
	MRI: Right nipple inversion and enhancement with thickening of covering skin, compatible with Paget’s disease
October 2024	Surgery: Right breast central type partial mastectomy and sentinel node dissection
November 2024	Pathology: Paget’s disease with high-grade multifocal ductal carcinoma in situ
November 2024	Follow-up: Radiation therapy and outpatient department regular checkup, showing good recovery

Full Size Table

Citation: Tsai CY, Lo TC, Yu JC, Hong ZJ, Sung YK. Paget’s disease of the nipple with occult ductal carcinoma in situ despite negative conventional imaging: A case report. World J Clin Cases 2026; 14(16): 120049
URL: https://www.wjgnet.com/2307-8960/full/v14/i16/120049.htm
DOI: https://dx.doi.org/10.12998/wjcc.v14.i16.120049

Tsai CY, Lo TC, Yu JC, Hong ZJ, Sung YK. Paget’s disease of the nipple with occult ductal carcinoma in situ despite negative conventional imaging: A case report. World J Clin Cases 2026; 14(16): 120049 [DOI: 10.12998/wjcc.v14.i16.120049]

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