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World J Clin Cases. Jun 6, 2026; 14(16): 120049
Published online Jun 6, 2026. doi: 10.12998/wjcc.v14.i16.120049
Published online Jun 6, 2026. doi: 10.12998/wjcc.v14.i16.120049
Paget’s disease of the nipple with occult ductal carcinoma in situ despite negative conventional imaging: A case report
Chih-Yan Tsai, Tzu-Chun Lo, Department of Medicine, National Defense Medical University, Taipei 114201, Taiwan
Jyh-Cherng Yu, Zhi-Jie Hong, Department of General Surgery, Tri-Service General Hospital, Taipei 114201, Taiwan
Yu-Kai Sung, Department of Pathology and Parasitology, Tri-Service General Hospital, National Defense Medical Center, Taipei 114201, Taiwan
Author contributions: Tsai CY and Yu JC were responsible for the clinical care of the patient, data collection, and study design; Tsai CY, Lo TC, and Yu JC performed the manuscript writing and analysis; Sung YK interpreted the pathological findings; Yu JC and Hong ZJ provided senior supervision and edited the manuscript for intellectual content; and all authors read and approved the final version of the manuscript.
AI contribution statement: ChatGPT and Gemini were utilized during the preparation of this manuscript. AI tools were used exclusively for language polishing, grammar checking, and spelling correction to improve the readability and formal tone of the manuscript. The main text content was independently written by us, and no AI was used in study design or result interpretation. All figures and tables were created by ourselves.
Informed consent statement: Written informed consent was obtained from the patient for publication of this case report and any accompanying images.
Conflict-of-interest statement: All authors declare that they have no conflicts of interest to disclose related to this work.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Jyh-Cherng Yu, MD, PhD, Department of General Surgery, Tri-Service General Hospital, No. 325, Section 2, Chenggong Road, Neihu District, Taipei 114201, Taiwan. doc20106@mail.ndmutsgh.edu.tw
Received: February 13, 2026
Revised: April 3, 2026
Accepted: April 22, 2026
Published online: June 6, 2026
Processing time: 98 Days and 12.5 Hours
Revised: April 3, 2026
Accepted: April 22, 2026
Published online: June 6, 2026
Processing time: 98 Days and 12.5 Hours
Core Tip
Core Tip: Mammary Paget’s disease, also known as Paget’s disease of the breast, may present as chronic nipple eczema without a detectable underlying malignant lesion on conventional imaging. In this case, diagnosis required repeat biopsy and magnetic resonance imaging despite initially benign imaging findings. Clinicians should maintain a high index of suspicion and pursue histopathologic evaluation when unilateral nipple-areolar dermatitis persists, even in the absence of radiologic evidence of malignancy.