Herpes simplex encephalitis associated with infliximab therapy for ulcerative colitis: A case report

doi:10.12998/wjcc.v14.i11.119107

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Apr 16, 2026 (publication date) through Apr 15, 2026

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World Journal of Clinical Cases

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Clin Cases. Apr 16, 2026; 14(11): 119107
Published online Apr 16, 2026. doi: 10.12998/wjcc.v14.i11.119107

Table 1 Summary of reported cases of herpes virus infections associated with tumor necrosis factor alpha inhibitors

Ref.	Medication	Treated condition	Timing of symptoms	Virus type
Nicolai et al[6], 2016	Etanercept	Juvenile idiopathic arthritis	Not specified	Varicella-Zoster
Bradford et al[3], 2009	Adalimumab, infliximab	Rheumatoid arthritis	15 months, 24 months	HSV-1
Schepers et al[7], 2014	Adalimumab	Psoriasis	24 months	HSV-1
Crusio et al[8], 2014	Etanercept	Psoriatic arthritis	Not specified	HSV-1

HSV-1: Herpes simplex virus 1; TNF-α: Tumor necrosis factor-alpha.

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Citation: Aleissa M, Busbait SA, Bhullar R, Singh JP, Bhullar JS, Mittal VK. Herpes simplex encephalitis associated with infliximab therapy for ulcerative colitis: A case report. World J Clin Cases 2026; 14(11): 119107
URL: https://www.wjgnet.com/2307-8960/full/v14/i11/119107.htm
DOI: https://dx.doi.org/10.12998/wjcc.v14.i11.119107