Acute pancreatitis secondary to small-cell lung cancer metastasis: A case report and literature review

Table 1 Summary of the literature search conducted

Ref.	Year	Article type	Diagnosis	Treatment	Outcomes
Levine and Danovitch[55]	1973	Case report	SCLC with pancreatic metastasis	Conservative management	Resolution of AP with supportive care; SCLC diagnosis confirmed later
Yeung et al[56]	1979	Case report	SCLC with metastasis-induced AP	Conservative management	Resolution of AP after conservative treatment
Schmitt[57]	1985	Case report	Metastatic SCLC with pancreatitis and diabetes	Supportive care	Clinical presentation of both pancreatitis and diabetes
Allan et al[58]	1985	Case report	SCLC with associated AP	Conservative management	Resolution of AP with conservative therapy
Hall et al[59]	1987	Case report	Oat cell carcinoma with AP	Symptomatic treatment	Diagnosis of AP revealed metastatic SCLC
Noseda et al[40]	1987	Case report	AP as sole manifestation of SCLC	Conservative management	AP resolved with supportive care
Evans et al[60]	1988	Case report	Necrotizing pancreatitis and diabetes due to metastatic SCLC	Supportive care	Associated with disseminated disease
Chowhan et al[61]	1990	Case report	Metastasis-induced AP	Chemotherapy	Symptom resolution after treatment
Maclennan et al[62]	1993	Case report	SCLC-induced AP	Chemotherapy	Symptom resolution
Stewart et al[63]	1993	Case report	SCLC presenting as AP	Conservative management	Symptom resolution; SCLC diagnosis confirmed
Huang et al[64]	2005	Case report	AP and Budd-Chiari syndrome due to SCLC	Supportive and systemic therapy	Initial manifestation of SCLC
Tanaka et al[65]	2009	Case report	Metastasis-induced AP from SCLC	Conservative management	Resolution of AP
Wurm Johansson et al[41]	2012	Case report	Pancreatic metastases from SCLC causing AP	Conservative management	AP resolved; detected by EUS
Hussain et al[66]	2012	Case report	SCLC presenting as AP	Conservative management	Resolution of AP
Leung et al[67]	2013	Case report	SCLC metastasis-induced pancreatitis	Supportive care	AP resolved with management
Khan et al[68]	2014	Case report	SCLC with AP as initial manifestation	Conservative management	Improved with supportive care
Okutur et al[51]	2015	Case report	Metastasis-induced AP in SCLC	Chemotherapy (cisplatin and irinotecan) + radiotherapy	Resolution of AP; tumor control at 6 months
Hernanz et al[69]	2016	Case report	Pancreatitis as first manifestation of SCLC	Conservative management	Favorable outcome
Yu et al[38]	2019	Retrospective study	SCLC with AP due to metastases	Systemic chemotherapy vs supportive care alone	Chemotherapy improved survival
Zhang et al[50]	2023	Case report	Recurrent SCLC transformation with AP after adenocarcinoma surgery	Radiotherapy	Resolution of AP; tumor control at 6 months
Jing et al[46]	2024	Case report	Lung adenocarcinoma with SCLC transformation causing AP	Chemotherapy (etoposide + cisplatin)	Resolution of AP; transformation confirmed
Xiao and Gu[47]	2025	Case report	Refractory SCLC with pancreatic metastasis	Chemotherapy + PD-1 (albumin with paclitaxel + atezolizumab)	Resolution of AP; tumor control at 3 months

AP: Acute pancreatitis; EUS: Endoscopic ultrasound; PD-1: Programmed cell death protein 1; SCLC: Small-cell lung cancer.