Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 26, 2025; 13(27): 107805
Published online Sep 26, 2025. doi: 10.12998/wjcc.v13.i27.107805
Acute pancreatitis secondary to small-cell lung cancer metastasis: A case report and literature review
Miguel Suárez, Soraya Simón, Raquel Martínez, JAS Crespo
Miguel Suárez, Raquel Martínez, Department of Gastroenterology, Virgen de la Luz Hospital, Cuenca 16002, Castille-La Mancha, Spain
Miguel Suárez, Raquel Martínez, Medical Analysis Expert Group, Universidad de Castilla-La Mancha, Cuenca 16071, Castille-La Mancha, Spain
Miguel Suárez, Raquel Martínez, Medical Analysis Expert Group, Instituto de Investigación Sanitaria de Castilla-La Mancha, Toledo 45071, Castille-La Mancha, Spain
Soraya Simón, JAS Crespo, Department of Oncology, Virgen de la Luz Hospital, Cuenca 16002, Castille-La Mancha, Spain
Author contributions: Suárez M, Martínez R, Simón S and Crespo JAS participated in the design, editing, and data collection of the manuscript; Suárez M, Martínez R and Simón S contributed to the review of the literature and writing; All authors have reviewed and approved the paper.
Informed consent statement: Informed written consent was obtained from the patient for publication of this case report.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Miguel Suárez, MD, PhD, Associate Chief Physician, Department of Gastroenterology, Virgen de la Luz Hospital, 1 Hermandad Donantes De Sangre, Cuenca 16002, Castille-La Mancha, Spain. msuarezmatias@sescam.jccm.es
Received: March 31, 2025
Revised: April 22, 2025
Accepted: June 19, 2025
Published online: September 26, 2025
Processing time: 129 Days and 19.1 Hours
Core Tip

Core Tip: Acute pancreatitis secondary to pancreatic metastases from small-cell lung cancer is an extremely rare entity, with few cases reported in the literature. This case highlights the importance of considering metastatic involvement in unexplained acute pancreatitis and reinforces the role of imaging for early diagnosis. Our findings suggest that targeted oncologic therapy, particularly chemotherapy, may be considered part of the first-line treatment in these situations. Further studies are needed to establish standardized management protocols and improve outcomes in this challenging clinical scenario.