Low salivary uric acid levels are independently associated with periodontitis

Table 1 Description of periodontal state in all subjects of the study, n (%)/median (25^th-75^th percentiles)

	Total (n = 119)	Subjects without periodontitis (n = 60)	Subjects with periodontitis (n = 61)	Uric acid (nmol/mL)	P value
					0.01
Periodontal health	39 (32.2)	39 (65.0)	0	126 (79-203)
Localized gingivitis	21 (17.4)	21 (35.0)	0	112 (86-142)
Periodontitis stage I	17 (14.0)	0	17 (27.9)	102 (53-137)
Periodontitis stage II	24 (19.8)	0	24 (39.3)	93 (62-171)
Periodontitis stage III	13 (10.7)	0	13 (21.3)	86 (53-111)
Periodontitis stage IV	7 (5.8)	0	7 (11.5)	61 (21-94)

Table 2 Comparisons between subjects with and without periodontitis, n (%)/median (25^th-75^th percentiles)

	Subjects without periodontitis (n = 60)	Subjects with periodontitis (n = 61)	P value
Age (years)	41 (34-49)	60 (52-68)	< 0.001
Salivary uric acid (nmol/mL)	112 (82-176)	89 (54-119)	0.002
Body mass index (kg/m²)	24.8 (22.9-26.7)	24.8 (22.6-28.4)	0.81
Sex female	40 (66.7)	38 (62.3)	0.71
Arterial hypertension	3 (5.0)	19 (31.1)	0.001
Diabetes mellitus	0	5 (8.2)	0.06
Obesity	7 (11.9)	9 (14.8)	0.79
Never smoker	47 (78.3)	26 (42.6)	< 0.001
Coffee	51 (85.0)	54 (88.5)	0.60
Tea	5 (8.3)	3 (4.9)	0.49
Alcohol	27 (45.0)	31 (50.8)	0.59
Rheumatoid arthritis	1 (1.7)	4 (6.6)	0.37
Immunosupressive therapy	1 (1.7)	3 (4.9)	0.62
Radiotherapy	0	3 (4.9)	0.24
Metrotexate	1 (1.7)	0	0.50

Table 3 Multiple logistic regression analyses to determine factors associated with periodontitis

	Odds ratio	95%CI	P value
Salivary uric acid levels < 111 nmol/mL (yes vs non)	6.14	2.015-18.721	0.001
Age (years)	1.13	1.073-1.197	< 0.001
Never smoker (yes vs non)	0.44	0.154-1.254	0.12
Arterial hypertension (yes vs non)	1.49	0.289-7.661	0.63