Editorial
Copyright ©The Author(s) 2024.
World J Clin Cases. Sep 16, 2024; 12(26): 5854-5858
Published online Sep 16, 2024. doi: 10.12998/wjcc.v12.i26.5854
Table 1 Classification, embryogenesis, and tumorigenicity of paired box protein family proteins
Group in PAX family
Member in PAX family
Expression site during embryogenesis
Involvement in tumorigenicity
IPAX1Skeleton, thymus, pharyngeal pouch
PAX9Skeleton, teeth, thymus
PAX2Kidney, CNSBladder and renal cancers
IIPAX5B cells, CNSLymphomas
PAX8Kidneys, thyroid gland, CNSThyroid, ovarian, and cervical cancers
IIIPAX3Neural crest, CNS, muscleMelanoma, rhabdomyosarcoma
PAX7Same as aboveRhabdomyosarcoma
IVPAX4Pancreas, gut
PAX5Pancreas, gut, and eyesGastrointestinal cancers