Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 16, 2024; 12(26): 5854-5858
Published online Sep 16, 2024. doi: 10.12998/wjcc.v12.i26.5854
Paired box proteins as diagnostic biomarkers for endocervical adenocarcinoma
Jia-Hui Zhou, Xiang-Ning Zhang
Jia-Hui Zhou, Pathology Department, Lishui Central Hospital, Lishui 323000, Zhejiang Province, China
Xiang-Ning Zhang, Pathophysiology Department, Guangdong Medical University, Dongguan 523808, Guangdong Province, China
Author contributions: Zhou JH and Zhang XN conceived the idea and performed the study; Zhou JH prepared the primary draft, figures, and table; Zhang XN corrected the manuscript and revised the figures and table; Both authors read and approved the final version of the paper and agreed on its submission.
Conflict-of-interest statement: All the authors report having no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiang-Ning Zhang, MD, PhD, Associate Professor, Pathophysiology Department, Guangdong Medical university, No. 1 Xincheng Avenue, Songshan Lake Scientific and Industrial Park, Dongguan 523808, Guangdong Province, China. zhangxn_2006@126.com
Received: April 5, 2024
Revised: May 12, 2024
Accepted: May 23, 2024
Published online: September 16, 2024
Processing time: 109 Days and 2.7 Hours
Core Tip

Core Tip: Paired box proteins (PAXs) are a family of transcription factors that play an important role in the embryogenesis of different tissues through the regulation of gene expression. PAX 2, 5, and 8 are expressed in the sites of mesonephric tissues, and their deregulation contributes to the genesis of urogenital tumors such as cervical and ovarian cancers. Immunohistochemical staining and in situ hybridization tests revealed that the specimens of endocervical adenocarcinoma were positive for the transcription factor PAX8 and human papillomavirus. It is proposed that combined with mucin of glandular tumor, PAX8 can be used as a diagnostic marker for cervical adenocarcinoma.