Efficacy and anti-inflammatory analysis of glucocorticoid, antihistamine and leukotriene receptor antagonist in the treatment of allergic rhinitis

Table 1 Comparison of general information between the two groups (n, mean ± SD)

Group	Gender (Male/Female)	Average age (yr)	Course of disease (wk)	Body mass index (kg/m2)
Control group (40)	18/22	5.70 ± 1.32	5.6 (3.7-7.9)	27.78 ± 2.32
Observation group (40)	17/23	5.69 ± 1.66	5.5 (3.1-7.7)	27.62 ± 2.66
χ2/t value	0.051	0.03	0.04	0.02
P value	0.822	0.976	0.965	0.984

Table 2 Comparison of the symptoms and signs scores of the two groups of patients before and after treatment (mean ± SD)

Group		Symptom score				Physical sign score
		Nasal itching score	Sneeze score	Runny nose score	Nasal congestion score
Control group	Before therapy	2.14 ± 0.18	2.08 ± 0.32	1.84 ± 0.30	1.79 ± 0.22	2.13 ± 0.27
	After treatment	1.76 ± 0.63a	1.45 ± 0.26a	1.36 ± 0.06a	1.37 ± 0.31a	1.44 ± 0.23a
Observation group	Before therapy	2.04 ± 0.61	2.03 ± 0.10	1.88 ± 0.80	1.82 ± 0.39	2.25 ± 0.44
	After treatment	1.32 ± 0.31a,b	1.09 ± 0.26a,b	0.92 ± 0.24a,b	1.21 ± 0.31a,b	1.17 ± 0.37a,b

^aP < 0.05 vs before treatment.

^bP < 0.05 vs the control group.

Table 3 Comparison of serum inflammatory indexes between the two groups (mean ± SD)

Group		IL-6 (ng/L)	TNF-α (pg/L)	IL-10 (ng/L)	sICAM-1 (μg/L)	LTD4 (mg/kg)
Control group	Before therapy	11.78 ± 2.32	55.34 ± 7.40	26.51 ± 6.32	40.78 ± 7.32	517.94 ± 23.40
	After treatment	6.62 ± 1.66	22.76 ± 6.64	16.55 ± 6.11	32.62 ± 5.66	206.96 ± 19.24
Observation group	Before therapy	11.78 ± 2.32	55.28 ± 7.80	26.81 ± 4.39	40.93 ± 7.27	517.75 ± 10.44
	After treatment	4.62 ± 0.66	19.19 ± 4.74	13.41 ± 3.31	26.74 ± 3.23	158.37 ± 10.37

IL: Interleukin; TNF-α: Tumor necrosis factor-alpha; sICAM-1: Soluble Intercellular Adhesion Molecule-1; LTD4: Leukotriene D4.

Table 4 Comparison of adverse reactions between the two groups of patients (mean ± SD)

Group	Dry nose	Dry throat discomfort	Bitter	Minor erosive osmosis of nasal mucosa	Adverse reaction rate
Control group (40)	1	3	4	3	11 (27.5)
Observation group (40)	0	2	1	0	3 (7.5)
t value					5.541
P value					0.019