Copyright
©The Author(s) 2023.
World J Clin Cases. Oct 6, 2023; 11(28): 6670-6679
Published online Oct 6, 2023. doi: 10.12998/wjcc.v11.i28.6670
Published online Oct 6, 2023. doi: 10.12998/wjcc.v11.i28.6670
Name | Source | Receptor | Effect on pancreatic islet secretion |
ACh | Vagus nerve | M3 | ↑↑↑ |
NO | Vagus nerve, beta cells | sGC | Low concentration ↑, high concentration ↓ |
GRP | Vagus nerve | GRPR | ↑ |
VIP | Vagus nerve | VIP-2 | ↑ |
PACAP | Vagus nerve, gut-pancreas nerve | PACAP-3 | ↑ |
5-HT | Vagus nerve, gut-pancreas nerve, beta cells | Htr1 | ↑↑ |
NE | Sympathetic nerves | α2, β2 | α2 receptors ↑, β2 receptors ↓↓ |
Galanin | Sympathetic nerves | GALR1 | ↓ |
NPY | Sympathetic nerves | Y2 | ↓ |
DA | Sympathetic nerves, beta cells | D2, D3 | D2↑, D3↓ |
CGRP | Sensory nerves | CGRP | ↓ |
SP | Sensory nerves | NK1 | ↑ |
Cholecystokinin | Sensory nerves | CCK | ↓ |
- Citation: Kong CC, Cheng JD, Wang W. Neurotransmitters regulate β cells insulin secretion: A neglected factor. World J Clin Cases 2023; 11(28): 6670-6679
- URL: https://www.wjgnet.com/2307-8960/full/v11/i28/6670.htm
- DOI: https://dx.doi.org/10.12998/wjcc.v11.i28.6670