Observational Study
Copyright ©The Author(s) 2023.
World J Clin Cases. Apr 16, 2023; 11(11): 2443-2451
Published online Apr 16, 2023. doi: 10.12998/wjcc.v11.i11.2443
Table 1 Demographic and clinical characteristics of severe hyperbilirubinemia, n (%)
Basic data
Cases
Sex
Male346 (59.66)
Female234 (40.34)
Delivery pattern
Caesarean section265 (45.69)
Vaginal delivery315 (54.31)
Feeding pattern
Breast feeding174 (29.90)
Mixed feeding195 (33.62)
Formula feeding165 (28.45)
Unknown46 (7.93)
Proportion of exchange transfusion level213 (36.72)
Prolonged jaundice52 (8.97)
Bilirubin encephalopathy20 (3.45)
Table 2 UGT1A1*6 variant combination with glucose-6-phosphate dehydrogenase deficiency in 94 cases of severe neonatal hyperbilirubinemia

G6PD deficiency
G6PD normal
Total
P value
G211A variation
Wild type1632480.787
c.211 hetereozygote142337
c.211 homozygote459
Total346094
Table 3 Comparison of UGT1A1*6 variant between neonates with severe hyperbilirubinemia and the control group

Case
Control1
P value
G211A variation
Wild type4851< 0.001
c.211 hetereozygote3713
c.211 homozygote91
Total9465