Identification of circ_0000375 and circ_0011536 as novel diagnostic biomarkers of colorectal cancer

Table 1 Clinicopathological characteristics of participants

	Tissues		Serums
	HC (n = 24)	CRC (n = 34)	HC (n = 28)	CRC (n = 56)	AS (n = 14)
Age (yr) (M) (P25, P75)	62.0 (55.0, 69.0)	64.5 (58.8, 73.0)	63.5 (56.3, 71.8)	66.0 (60.3, 75.0)	61.0 (49.5, 68.3)
Gender
Male	17	23	15	39	9
Female	7	11	13	17	5
TNM stage
Ⅰ		9		9	2
Ⅱ		9		16	4
Ⅲ		10		21	6
Ⅳ		6		10	2
Tumor size
≤ 5 cm		20		29	9
> 5 cm		14		27	5
Tumor location
Left colon		6		12	3
Right colon		5		9	2
Rectum		23		35	9
Lymph node metastasis
No		19		35	6
Yes		15		21	8

HC: Healthy control; CRC: Colorectal cancer; AS: After surgery.

Table 2 Associations between the expressions of two Circular ribonucleic acids and clinicopathological features in colorectal cancer tissues

		n	Circ_0000375 expression		P value	Circ_0011536 expression		P value
			Low	High		Low	High
Age (yr)					0.730			0.300
≤ 65		19	9	10		8	11
> 65		15	8	7		9	6
Gender					0.714
Female		11	6	5		5	6	0.714
Male		23	11	12		12	11
TNM stage					0.169			0.039a
Ⅰ-Ⅱ		18	11	7		12	6
Ⅲ-Ⅳ		16	6	10		5	11
Tumor size					0.486			1.000
≤ 5 cm		20	9	11		10	10
> 5 cm		14	8	6		7	7
Tumor location					0.271			0.714
Colon		11	4	7		5	6
Rectum		23	13	10		12	11
Lymph node metastasis					0.084			0.016a
No		19	12	7		13	6
Yes		15	5	10		4	11

^aP < 0.05.