Yin TF, Du SY, Zhao DY, Sun XZ, Zhou YC, Wang QQ, Zhou GYJ, Yao SK. Identification of circ_0000375 and circ_0011536 as novel diagnostic biomarkers of colorectal cancer. World J Clin Cases 2022; 10(11): 3352-3368 [PMID: 35611198 DOI: 10.12998/wjcc.v10.i11.3352]
Corresponding Author of This Article
Shu-Kun Yao, MD, PhD, Doctor, Professor, Graduate School, Peking University China-Japan Friendship School of Clinical Medicine, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com
Research Domain of This Article
Oncology
Article-Type of This Article
Clinical and Translational Research
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This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Yin TF, Du SY, Zhao DY, Sun XZ, Zhou YC, Wang QQ, Zhou GYJ, Yao SK. Identification of circ_0000375 and circ_0011536 as novel diagnostic biomarkers of colorectal cancer. World J Clin Cases 2022; 10(11): 3352-3368 [PMID: 35611198 DOI: 10.12998/wjcc.v10.i11.3352]
World J Clin Cases. Apr 16, 2022; 10(11): 3352-3368 Published online Apr 16, 2022. doi: 10.12998/wjcc.v10.i11.3352
Identification of circ_0000375 and circ_0011536 as novel diagnostic biomarkers of colorectal cancer
Teng-Fei Yin, Shi-Yu Du, Dong-Yan Zhao, Xi-Zhen Sun, Yuan-Chen Zhou, Qian-Qian Wang, Ge-Yu-Jia Zhou, Shu-Kun Yao
Teng-Fei Yin, Shi-Yu Du, Yuan-Chen Zhou, Qian-Qian Wang, Shu-Kun Yao, Graduate School, Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China
Shi-Yu Du, Dong-Yan Zhao, Ge-Yu-Jia Zhou, Shu-Kun Yao, Department of Gastroenterology, China-Japan Friendship Hospital, Beijing 100029, China
Dong-Yan Zhao, Xi-Zhen Sun, Ge-Yu-Jia Zhou, Graduate School, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China
Xi-Zhen Sun, Department of Gastroenterology, Beijing Jishuitan Hospital, Beijing 100035, China
Author contributions: Yin TF conceived and designed the study, performed sample collection and formal analysis, and prepared the original draft; Du SY, Zhao DY and Sun XZ participated in sample acquisition, data analysis and manuscript revision; Zhou YC, Wang QQ and Zhou GYJ reviewed and edited the manuscript critically; Yao SK designed and supervised the study, revised the manuscript, and obtained the funding; all authors read and approved the final manuscript.
Supported bythe National Key Development Plan for Precision Medicine Research, No. 2017YFC0910002.
Institutional review board statement: This study was approved by the Ethics Committee of China-Japan Friendship Hospital, No. 2018-116-K85-1.
Informed consent statement: All participants signed written informed consent.
Conflict-of-interest statement: There are no conflicts of interest to report.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shu-Kun Yao, MD, PhD, Doctor, Professor, Graduate School, Peking University China-Japan Friendship School of Clinical Medicine, No. 2 Yinghua East Road, Chaoyang District, Beijing 100029, China. shukunyao@126.com
Received: October 29, 2021 Peer-review started: October 29, 2021 First decision: December 27, 2021 Revised: December 30, 2021 Accepted: February 12, 2022 Article in press: February 12, 2022 Published online: April 16, 2022 Processing time: 161 Days and 5.7 Hours
Core Tip
Core Tip: The dysregulation and biological functions of circular ribonucleic acids (circRNAs) in colorectal cancer (CRC) have not been well elucidated. In this study, circ_0000375 and circ_0011536 were observed to be downregulated in CRC tissues, serum samples and cell lines. These 2 circRNAs were validated as biomarker candidates in tissues and serum samples with high diagnostic performance. Overexpression of circ_0000375 and circ_0011536 inhibited the growth, migration and invasion of CRC cells. Furthermore, miR-1182 and miR-1246 were upregulated in CRC tissues as target microRNA of circ_0000375 and circ_0011536, respectively. Overall, circ_0000375 and circ_0011536 may serve as diagnostic biomarkers and function as tumor suppressors in CRC.
