Hepatocyte nuclear factor 1B mutation in a Chinese family with renal cysts and diabetes syndrome: A case report

Figure 1 Computed tomography images and classic histological features of the kidney. A and B: Abdominal computed tomography revealed multiple renal cysts in the proband (orange arrow), and cystic structure with serous-like substances was visible in tubular lumens; C: Section stained with hematoxylin-eosin; D: Section stained with Periodic acid-Schiff.

Figure 2 Oral glucose tolerance test. A: Glucose; B: Insulin; C: C-peptide concentration during oral glucose tolerance test.

Figure 3 Mutation analysis of the renal cysts and diabetes patient. A: Sanger sequencing of the renal cysts and diabetes patient (upper panel) and her parents (lower panel). Black arrow indicates the mutation position; B: The amino acid sequence of the DNA-binding domain of NHF1B is highly conserved among species.