Primary myelofibrosis with concurrent CALR and MPL mutations: A case report

Figure 1 Computed tomography images showing splenomegaly. A and B: Abdominal computed tomography images showing that the inferior margin of the spleen was lower than that of the liver (A) and reached the level of abdominal aortic bifurcation (B).

Figure 2 Bone marrow aspiration findings. A: Dacrocytes were easily observed; B-D: Images showing the presence of megakaryocyte atypia, including abnormal nuclear-cytoplasmic ratios, malformed nucleus (B), abnormal chromatin clumping with hyperchromatic nucleus (C), and extensive lobulation of the nucleus (D).

Figure 3 Bone marrow biopsy findings. A: Hematoxylin and eosin staining showed megakaryocytic proliferation and clustered distribution (magnification, 200 ×); B: Gomori staining showed diffuse and dense increase in reticulin fibres (magnification, 200 ×).