Sister Mary Joseph’s nodule in endometrial carcinoma: A case report

Figure 1 Photograph of the umbilical mass. A: Arrow shows the umbilical mass when the patient had not yet been treated with systemic chemotherapy; B: After three cycles of systemic chemotherapy, the size of the umbilical mass significantly reduced.

Figure 2 Coronal abdominal computed tomography scan of the 75-year-old woman with endometrial carcinoma. Arrows point to the umbilical mass. A: Scan when the patient first visited the doctor with the umbilical mass (39 mm × 33 mm × 32 mm); B: Scan after the patient received four cycles of systemic chemotherapy (39 mm × 19 mm × 16 mm).

Figure 3 Morphology of metastatic specimens (Hematoxylin and eosin, × 100) and immumohistochemical staining of cancer cells in metastatic lesions (× 200). A: Dark purple shows adenoid cancer cells; B: Positive staining of umbilical metastasis with anti-P53 antibody; C: Positive staining of umbilical metastasis with anti-P16 antibody; D: Positive staining of umbilical metastasis with anti-ER antibody; E: Positive staining of umbilical metastasis with anti-WT-1 antibody; F: Positive staining of umbilical metastasis with anti-PAX-8 antibody; G: Positive staining of umbilical metastasis with anti-CK7 antibody; H: Positive staining of umbilical metastasis with anti-Ki-67 antibody.