Kaposi sarcoma following dupilumab treatment for bullous pemphigoid: A case report and review of literature

Figure 1 Clinical presentation of Kaposi sarcoma lesions after 32 weeks of treatment. A-C: Multiple violaceous-red papules on both feet after 32 weeks of treatment.

Figure 2 Histopathological features of Kaposi sarcoma (hematoxylin and eosin staining, × 200). Slit-like vascular spaces containing extravasated erythrocytes are observed, surrounded by proliferating spindle cells, consistent with the characteristic pathological features of Kaposi sarcoma.

Figure 3 Immunohistochemical staining of Kaposi sarcoma lesions (× 200). A-F: Representative immunohistochemical staining demonstrating tumor cell markers in Kaposi sarcoma tissue. Tumor cells were positive for ERG (A), CD31 (B), CD34 (C), human herpesvirus-8 (partial positive) (D), D2-40 (E), and Ki67 (approximately 60% positive) (F).