Double plasma molecular adsorption system for Stevens–Johnson syndrome/toxic epidermal necrolysis: A case report

Figure 1 Facial symptoms of the patient with Stevens–Johnson syndrome and toxic epidermal necrolysis after coronavirus disease 2019 diagnosis. A: Skin injury on the upper arm on day 9 of the disease course; B and C: On day 13 of the disease course, the skin rash on her face and arm started falling off and was resolved after three courses of double plasma molecular adsorption system.

Figure 2 Disease flowchart. DPMAS: Double plasma molecular adsorption system; ALT: Alanine aminotransferase; TBIL: Total bilirubin; ALP: Alkaline phosphatase; LB: Liver biopsy.

Figure 3 Skin changes after recovery, and histopathological features of the liver. A: On day 40 of the disease course, the facial skin gradually returned to normal, but with pigmentation; B: Liver histopathology revealed cholestasis of central hepatocytes without apparent inflammation and necrosis.

Figure 4 After stopping the double plasma molecular adsorption system treatment, new skin lesions appeared. A-C: New skin lesions on the inner thighs, arms, and face.