Double plasma molecular adsorption system for Stevens–Johnson syndrome/toxic epidermal necrolysis: A case report

doi:10.12998/wjcc.v12.i7.1371

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 12, Issue 7

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (5022)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-4) series, Tables (1-1) series.

Item

Count

PDF

214

HTML

2467

Figures (1-4)

479

Tables (1-1)

515

Sum=3675

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

273

Download

865

Sum=1138

Mar 6, 2024 (publication date) through Feb 26, 2026

Times Cited of This Article

Times Cited (2)

Journal Information of This Article

Publication Name

World Journal of Clinical Cases

ISSN

2307-8960

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Report

World J Clin Cases. Mar 6, 2024; 12(7): 1371-1377
Published online Mar 6, 2024. doi: 10.12998/wjcc.v12.i7.1371

Double plasma molecular adsorption system for Stevens–Johnson syndrome/toxic epidermal necrolysis: A case report

You-Wen Tan, Li-Ping Liu, Kai Zhang

You-Wen Tan, Li-Ping Liu, Kai Zhang, Department of Hepatology, The Third Hospital of Zhenjiang Affiliated Jiangsu University, Zhenjiang 212003, Jiangsu Province, China

Author contributions: Tan YW, Liu LP and Zhang K contributed equally to the research, Tan YW designed the research; Liu LP and Zhang K collected and analyzed the data, and drafted the manuscript; Tan YW, Liu LP and Zhang K wrote and revised the manuscript; all authors have read and approved the final version to be published.

Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

Corresponding author: You-Wen Tan, MD, Chief Doctor, Professor, Department of Hepatology, The Third Hospital of Zhenjiang Affiliated Jiangsu University, No. 300 Daijiamen, Runzhou Distinct, Zhenjiang 212003, Jiangsu Province, China. tyw915@sina.com

Received: December 31, 2023
Peer-review started: December 31, 2023
First decision: January 16, 2024
Revised: January 19, 2024
Accepted: February 8, 2024
Article in press: February 8, 2024
Published online: March 6, 2024
Processing time: 60 Days and 20 Hours

Abstract

BACKGROUND

Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are very serious skin allergies, with an etiology related to infections and medication. Since the coronavirus disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus-2 has also been considered to cause SJS/TEN.

CASE SUMMARY

We report the case of a woman in her thirties who took acetaminophen after contracting COVID-19. After 3 d of fever relief, she experienced high fever and presented with SJS/TEN symptoms, accompanied by intrahepatic cholestasis. Three days of corticosteroid treatment did not alleviate the skin damage; therefore, double plasma molecular adsorption system (DPMAS) therapy was initiated, with treatment intervals of 48 h. Her skin symptoms improved gradually and were resolved after seven DPMAS treatments.

CONCLUSION

DPMAS therapy is beneficial for abrogating SJS/TEN because plasma adsorption and perfusion techniques reduce the inflammatory mediators (e.g., tumor necrosis factor-alpha and interleukin-10 and-12) speculated to be involved in the pathology of the skin conditions.

Keywords: Stevens-Johnson; Toxic epidermal necrolysis; COVID-19; Double plasma molecular adsorption system; SARS-CoV-2; Case report

Core Tip: A woman in her thirties took acetaminophen after contracting coronavirus disease 2019. After 3 d of fever relief, she experienced high fever, with Stevens–Johnson syndrome and toxic epidermal necrolysis symptoms and intrahepatic cholestasis. Because 3 d of corticosteroid treatment did not alleviate the skin damage, double plasma molecular adsorption system (DPMAS) therapy was initiated, with treatment intervals of 48 h. Her skin symptoms improved gradually and were completely resolved after seven DPMAS treatments.