Warthin-like papillary renal cell carcinoma: A case report

Figure 1 Computed axial tomography of the abdomen and pelvis. A and B: Computed tomography scan showing a slightly high-density lesion in the left kidney, approximately 4.7 cm × 3.8 cm in size, with continuous and significant enhancement on the enhanced scan.

Figure 2 Histological features associated with Warthin-like papillary renal cell carcinoma. A and B: The boundary between the tumor and the surrounding normal renal tissue is clear, the tumor is distributed in sheets, and lymphoid cell infiltration is observed in the tumor stroma (hematoxylin and eosin, × 40); C: The tumor cells are arranged in glandular or tubular form, with more lymphocyte infiltrates in the interstitial area, lymphatic follicle formation, and no fibrous septa (hematoxylin and eosin, × 100); D: The tumor cytoplasm is eosinophilic, the tumor nucleus is of medium size, nucleoli are seen, and the middle and upper part of the cell in the nucleus was located (hematoxylin and eosin, × 200).

Figure 3 Immunohistochemistry of Warthin-like papillary renal cell carcinoma. A-D: Immunohistochemical staining for CK7, P504S, PAX8 and Vimentin is diffuse in the tumor cells (× 100); E: The Ki-67 index of tumor cells is approximately 2% (× 100); F: Tumor mesenchymal lymphocytes partially expressed CD3 (× 100); G: Tumor mesenchymal lymphocytes partially expressed CD20 (× 100); H: Colloidal iron staining was negative (× 100).

Figure 4 Fluorescence in situ hybridization of chromosomes 7 and 17 in the nucleus of renal cell carcinoma. A: Fluorescence staining shows the triploid of chromosomes 7 (× 100); B: Fluorescence staining shows the triploid of chromosomes 17 (× 100).