Malignant transformation of biliary adenofibroma combined with benign lymphadenopathy mimicking advanced liver carcinoma: A case report

Figure 1 Computed tomography, magnetic resonance imaging and positron emission tomography/computed tomography images of liver mass and mediastinal lymphadenopathy. A: Abdominal contrast computed tomography, venous phase; B-D: Representative images from the MRI study (B: Venous phase; C: Sagittal venous phase; D: Diffusion weighted).

Figure 2 computed tomography images. A: Pulmonary computed tomography, mediastinal window; B: Representative positron emission tomography/computed tomography images, left, mediastinum, right, abdominal.

Figure 3 Macroscopic view of surgical specimens. A: Sectional appearance of the hepatic lesion; B: Enlarged mediastinal lymph node (multiple nodes merged). Bar = 1 cm.

Figure 4 Microscopic pathology of surgical specimens. A and B: H & E staining of hepatic lesion, (A) H & E × 100 (B) H & E × 200. The malignant component of a tumor consists of deformed fused glandular ducts that form a sieve, and cord-like structures. The neoplastic cells are of medium size with well-defined nucleoli, and most of the cytoplasm is pale, slightly acidophilic or vacuolated; C and D: Immunohistochemical staining of IgG4 and HHV8 in mediastinal lymph node (× 100). Bar = 100 μm.