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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 6, 2022; 10(25): 9104-9111
Published online Sep 6, 2022. doi: 10.12998/wjcc.v10.i25.9104
Published online Sep 6, 2022. doi: 10.12998/wjcc.v10.i25.9104
Malignant transformation of biliary adenofibroma combined with benign lymphadenopathy mimicking advanced liver carcinoma: A case report
Shao-Cheng Wang, Yan-Yan Chen, Hai-Yong Wang, Fu-Sheng Wu, Li-Song Teng, Department of Surgical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
Fei Cheng, Department of Pathology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
Author contributions: Wang SC and Chen YY collected, analyzed the patient data and wrote the manuscript; Cheng F conducted the pathological analysis; Teng LS, Wang SC and Wang HY performed the operation and were in charge of the patient; Teng LS and Wu FS reviewed the manuscript; all authors have read and approve the final manuscript.
Supported by Innovative Project of Medical and Health Science , Zhejiang Province, No. 2021RC002.
Informed consent statement: The patient's informed consent has been obtained in this case.
Conflict-of-interest statement: All the authors have no financial disclosures or conflicts of interest to declare.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Song Teng, PhD, Professor, Department of Surgical Oncology, First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310000, Zhejiang Province, China. lsteng@zju.edu.cn
Received: April 14, 2022
Peer-review started: April 14, 2022
First decision: May 30, 2022
Revised: June 12, 2022
Accepted: July 20, 2022
Article in press: July 20, 2022
Published online: September 6, 2022
Processing time: 133 Days and 20.2 Hours
Peer-review started: April 14, 2022
First decision: May 30, 2022
Revised: June 12, 2022
Accepted: July 20, 2022
Article in press: July 20, 2022
Published online: September 6, 2022
Processing time: 133 Days and 20.2 Hours
Core Tip
Core Tip: Biliary adenofibromas (BAFs) are rare primary hepatic neoplasms, some of which have potential of malignant transformation. Here we describe a rare case of malignant transformation of BAF presented with epigastric pain, whose imaging showed solitary liver mass combined with enlargement of multiple mediastinal and cervical lymph nodes, clinically mimicking a liver carcinoma with extensive lymph node metastasis. The patient was treated with curative resection of the neoplasm and has been recurrence-free for 12 mo. Our case is a rare manifestation of BAF and our experience supported that curative resection should be considered the primary treatment for BAFs with malignant transformation, which leads to a favorable prognosis.