Observational Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Dec 26, 2021; 9(36): 11320-11329
Published online Dec 26, 2021. doi: 10.12998/wjcc.v9.i36.11320
Yield of testing for micronutrient deficiencies associated with pancreatic exocrine insufficiency in a clinical setting: An observational study
Mustafa Jalal, Jennifer Anne Campbell, Solomon Tesfaye, Ahmed Al-Mukhtar, Andrew Derek Hopper
Mustafa Jalal, Jennifer Anne Campbell, Andrew Derek Hopper, Academic Department of Gastroenterology, Sheffield Teaching Hospitals, Sheffield S10 2JF, United Kingdom
Mustafa Jalal, Department of Infection, Immunology and Cardiovascular disease, University of Sheffield, Sheffield S10 2TN, United Kingdom
Solomon Tesfaye, Academic Unit of Diabetes and Endocrinology, Sheffield Teaching Hospitals, Sheffield S10 2JF, United Kingdom
Ahmed Al-Mukhtar, Department of Surgery, Sheffield Teaching Hospitals, Sheffield S10 2JF, United Kingdom
Author contributions: Jalal M contributed to study design, data collection, analysis and drafting the manuscript; Campbell JA contributed to data collection, interpretation of data and critically revised the manuscript; Tesfaye S and Al-Mukhtar A contributed to interpretation of data and critically revised the manuscript; Hopper AD contributed to study design, analysis, interpretation of data and critically revised the manuscript; all authors approved the final version of the manuscript.
Institutional review board statement: The study was approved by local research ethics committee (IRAS 210710).
Informed consent statement: Informed consent (STH 19471) was obtained from all patients.
Conflict-of-interest statement: Authors report no conflict of interest.
Data sharing statement: Data that support the finding of this study are available from corresponding author upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Mustafa Jalal, MBChB, MRCP, MSc, Research Fellow, Academic Department of Gastroenterology, Sheffield Teaching Hospitals, Glossop Road, Sheffield S10 2JF, United Kingdom. mustafa.jalal@nhs.net
Received: August 19, 2021
Peer-review started: August 19, 2021
First decision: October 2, 2021
Revised: October 17, 2021
Accepted: November 14, 2021
Article in press: November 14, 2021
Published online: December 26, 2021
Processing time: 125 Days and 21.5 Hours
Core Tip

Core Tip: Several studies have identified pancreatic exocrine insufficiency associated micronutrient deficiencies (PEI-MD), however, there is a paucity of information for PEI-MD prevalence in patients without chronic pancreatitis (CP) and the yield for testing for these PEI-MD in a clinical setting of suspected benign pancreatic diseases. We performed a clinical based prospective study to determine the yield of testing for PEI-MD when pancreatic exocrine insufficiency (PEI) is present and which specific micronutrients are most beneficial to test. We found high yield of micronutrients deficiency in PEI, in particular when CP was present.