Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2021; 9(30): 9108-9113
Published online Oct 26, 2021. doi: 10.12998/wjcc.v9.i30.9108
Dynamic changes in the radiologic manifestation of a recurrent checkpoint inhibitor related pneumonitis in a non-small cell lung cancer patient: A case report
Pei-Xin Tan, Wei Huang, Ping-Ping Liu, Yi Pan, Yan-Hai Cui
Pei-Xin Tan, Wei Huang, Ping-Ping Liu, Yi Pan, Yan-Hai Cui, Department of Radiation Oncology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong Province, China
Author contributions: Tan PX wrote the manuscript; Huang W, Liu PP and Pan Y collected clinical data; Cui YH reviewed the computed tomography scan images of the patient; and all authors have read and approved the final manuscript.
Informed consent statement: The patients provided informed written consent prior to study enrollment.
Conflict-of-interest statement: None reported. All authors have declared that there are no financial conflicts of interest with regard to this work.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan-Hai Cui, MD, Professor, Department of Radiology, Guangdong Provincial People's Hospital and Guangdong Academy of Medical Sciences, No. 106 Zhongshan Er Road, Guangzhou 510080, Guangdong Province, China. cuiyanhai_gpph@163.com
Received: January 27, 2021
Peer-review started: January 27, 2021
First decision: August 18, 2021
Revised: August 18, 2021
Accepted: September 14, 2021
Article in press: September 14, 2021
Published online: October 26, 2021
Processing time: 266 Days and 21.3 Hours
Core Tip

Core Tip: Checkpoint inhibitor-related pneumonitis (CIP) is one of the most concerning adverse events as it is uncommon but life threatening. This is the first case report on the unique dynamic changes in the radiologic features of CIP. This case showed that recurrent CIPs may occur repeatedly until the whole lung is involved, indicating that the follow-up period of CIP should be long enough, and the rechallenge of immune checkpoint inhibitor should be done with due caution.