Clinical and Translational Research
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 16, 2021; 9(29): 8671-8693
Published online Oct 16, 2021. doi: 10.12998/wjcc.v9.i29.8671
Prognostic implications of ferroptosis-associated gene signature in colon adenocarcinoma
Yan-Dong Miao, Zhi-Yong Kou, Jiang-Tao Wang, Deng-Hai Mi
Yan-Dong Miao, Jiang-Tao Wang, Deng-Hai Mi, The First Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu Province, China
Zhi-Yong Kou, Department of Oncology, The First Affiliated Hospital of Kunming Medical University, Kunming 650000, Yunnan Province, China
Deng-Hai Mi, Dean’s Office, Gansu Academy of Traditional Chinese Medicine, Lanzhou 730000, Gansu Province, China
Author contributions: Mi DH designed the research; Miao YD and Kou ZY performed the writing, data analysis, and prepared the figures and tables; Wang JT performed the dada validation; Miao YD and Kou ZY contributed equally to this work; All authors approved the final manuscript.
Institutional review board statement: TCGA and GEO belong to public databases. The patients involved in the database have obtained ethical approval. Users can download relevant data for free for research and publish relevant articles. Our study is based on open-source data, so there are no ethical issues and other conflicts of interest. Therefore, the current research was exempt from approval by the local ethics committee. The present study follows the data access strategy and publication guidelines of the TCGA and GEO databases.
Conflict-of-interest statement: All authors declare having no conflict of interests.
Data sharing statement: Bioinformatics analysis code and dataset available from the corresponding author at mi.dh@outlook.com.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Deng-Hai Mi, MD, Chief Doctor, Dean, Professor, Dean’s office, Gansu Academy of Traditional Chinese Medicine, No. 418 Guazhou Road, Qilihe District, Lanzhou 730000, Gansu Province, China. mi.dh@outlook.com
Received: March 25, 2021
Peer-review started: March 25, 2021
First decision: June 14, 2021
Revised: June 17, 2021
Accepted: August 19, 2021
Article in press: August 19, 2021
Published online: October 16, 2021
Processing time: 204 Days and 6.9 Hours
Core Tip

Core Tip: Colon adenocarcinoma is one of the most ordinary and fatal malignant tumors. Ferroptosis is a recently appeared type of programmed cell death process, which has the characteristics of iron-dependent lipid peroxide accumulation. In this work, we excavated five ferroptosis-related genes of colon adenocarcinoma from The Cancer Genome Atlas database. Then, we constructed a very accurate prognostic model based on the five genes (AKR1C1, AKR1C3, ALOX12, CRYAB, FDFT1). Our study also highlights the crucial roles of the risk score was an independent prognostic biomarker for colorectal cancer patients, and we validated these genes in the outside data access (GSE39582).