Multiple immune function impairments in diabetic patients and their effects on COVID-19

doi:10.12998/wjcc.v9.i24.6969

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World Journal of Clinical Cases

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World J Clin Cases. Aug 26, 2021; 9(24): 6969-6978
Published online Aug 26, 2021. doi: 10.12998/wjcc.v9.i24.6969

Multiple immune function impairments in diabetic patients and their effects on COVID-19

Zhong-Hua Lu, Wei-Li Yu, Yun Sun

Zhong-Hua Lu, Wei-Li Yu, Yun Sun, Department of Critical Care Medicine, The Second Affiliated Hospital, Anhui Medical University, Hefei 230601, Anhui Province, China

Author contributions: Lu ZH and Sun Y participated in the conception and drafted the manuscript; Yu WL helped draft the manuscript; all authors read and approved the final manuscript.

Supported by Doctoral Research Fund Project of the Second Affiliated Hospital of Anhui Medical University, No. 2018BSJJ005; and Clinical Medicine Discipline Construction Project of Anhui Medical University, No. 2021 Lcxk026.

Conflict-of-interest statement: The authors declare that they have no competing interests to disclose.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Yun Sun, MD, Associate Professor, Chief Doctor, Teacher, Department of Critical Care Medicine, The Second Affiliated Hospital, Anhui Medical University, No. 678 Furong Road, Hefei 230601, Anhui Province, China. sunyun15@163.com

Received: January 28, 2021
Peer-review started: January 28, 2021
First decision: February 25, 2021
Revised: March 18, 2021
Accepted: July 5, 2021
Article in press: July 5, 2021
Published online: August 26, 2021
Processing time: 207 Days and 10.6 Hours

Core Tip

Core Tip: Diabetes is an important predictor of coronavirus disease 2019 (COVID-19) morbidity and mortality. The immune response impairment presented by diabetes mellitus (DM) may be among the underlying mechanisms of the association between diabetes and COVID-19. DM patients with uncontrolled hyperglycemia are more prone to develop severe COVID-19 due to T cell dysfunction. Therefore, DM is often associated with impaired innate and adaptive immune function, thus greatly increasing the risk of severe acute respiratory syndrome coronavirus 2 infection in DM patients.