Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 16, 2021; 9(23): 6816-6823
Published online Aug 16, 2021. doi: 10.12998/wjcc.v9.i23.6816
Nasal metastases from neuroblastoma-a rare entity: Two case reports
Ying Zhang, Wen-Bin Guan, Rui-Fen Wang, Wen-Wei Yu, Rui-Qi Jiang, Yi Liu, Li-Feng Wang, Jia Wang
Ying Zhang, Wen-Bin Guan, Rui-Fen Wang, Wen-Wei Yu, Rui-Qi Jiang, Yi Liu, Li-Feng Wang, Jia Wang, Department of Pathology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
Author contributions: Zhang Y collected the data and drafted and revised the manuscript; Guan WB and Wang RF did the literature search; Yu WW, Jiang RQ and Liu Y conducted morphology, immunohistochemistry and fluorescence in situ hybridization analysis; Wang LF and Wang J contributed to the concept and design and approved the final version of the manuscript; all authors read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patients for publication of this report and any accompanying images.
Conflict-of-interest statement: Authors have nothing to disclose.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jia Wang, MD, Attending Doctor, Department of Pathology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, No. 1665 Kongjiang Road, Shanghai 200092, China. wangjia02@xinhuamed.com.cn
Received: January 26, 2021
Peer-review started: January 26, 2021
First decision: April 25, 2021
Revised: May 8, 2021
Accepted: June 22, 2021
Article in press: June 22, 2021
Published online: August 16, 2021
Processing time: 190 Days and 5.4 Hours
Core Tip

Core Tip: Nasal metastases from neuroblastoma (NB) is a rare disease that can be misdiagnosed in case of initial presentation with a nasal mass without a history of NB. In this study, we reported two pediatric cases of nasal metastases including one case without a history of NB. It can be difficult to differentiate between metastatic NB in the nose and olfactory neuroblastoma in the absence of a history of NB. Paired like homeobox protein 2B is very helpful for accurate diagnosis.