©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 16, 2021; 9(23): 6591-6607
Published online Aug 16, 2021. doi: 10.12998/wjcc.v9.i23.6591
Published online Aug 16, 2021. doi: 10.12998/wjcc.v9.i23.6591
Beta-carotene and its protective effect on gastric cancer
Qian-Hui Chen, Department of Intensive Care Unit, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Bao-Kang Wu, Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang 110004, Liaoning Province, China
Dan Pan, Li-Xuan Sang, Department of Geriatrics, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Bing Chang, Department of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
Author contributions: Chen QH and Sang LX designed the structure of the manuscript; Chen QH, Wu BK, Pan D, Chang B and Sang LX drafted the manuscript; Chen QH, Wu BK and Sang LX reviewed the literature; Pan D, Chang B and Sang LX critically revised the manuscript.
Supported by Innovative Talents Support Program of Institution of Higher Learning of Liaoning Province , No. 2018-478 ; and Science and Technology Support Program of Shenyang , No. 20-205-4-094 .
Conflict-of-interest statement: We declare no conflicts of interest.
Corresponding author: Bing Chang, PhD, Associate Professor, Department of Gastroenterology, First Affiliated Hospital of China Medical University, No. 155 Nanjing North Street, Heping District, Shenyang 110001, Liaoning Province, China. cb000216@163.com
Received: January 12, 2021
Peer-review started: January 12, 2021
First decision: May 13, 2021
Revised: May 16, 2021
Accepted: June 22, 2021
Article in press: June 22, 2021
Published online: August 16, 2021
Processing time: 205 Days and 8.1 Hours
Peer-review started: January 12, 2021
First decision: May 13, 2021
Revised: May 16, 2021
Accepted: June 22, 2021
Article in press: June 22, 2021
Published online: August 16, 2021
Processing time: 205 Days and 8.1 Hours
Core Tip
Core Tip: Beta-carotene is believed to prevent and treat many chronic diseases. Gastric cancer is one of the most important diseases it can treat. A few studies in the literature database describe the pathophysiology, therapy and clinical trials for gastric cancer and beta-carotene. However, this review summarizes the latest studies on the specific effect of beta-carotene on gastric cancer. It includes molecular mechanisms and clinical trials.