©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jul 26, 2021; 9(21): 6102-6109
Published online Jul 26, 2021. doi: 10.12998/wjcc.v9.i21.6102
Published online Jul 26, 2021. doi: 10.12998/wjcc.v9.i21.6102
Unusual immunohistochemical “null” pattern of four mismatch repair proteins in gastric cancer: A case report
Meng Yue, Jun-Ying Liu, Yue-Ping Liu, Department of Pathology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei Province, China
Author contributions: Yue M collected the patient’s clinical data, performed literature review, and drafted the whole manuscript; Liu JY assisted in data collection and literature review; Liu YP helped revise the manuscript; all authors read and approved the final manuscript.
Informed consent statement: The patient provided informed written consent prior to study enrollment.
Conflict-of-interest statement: The authors declare that they have no competing interests to report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Yue-Ping Liu, MD, PhD, Chief Doctor, Professor, Senior Scientist, Department of Pathology, The Fourth Hospital of Hebei Medical University, No. 12 Jiankang Road, Shijiazhuang 050011, Hebei Province, China. annama@163.com
Received: March 17, 2021
Peer-review started: March 17, 2021
First decision: April 4, 2021
Revised: April 16, 2021
Accepted: May 19, 2021
Article in press: May 19, 2021
Published online: July 26, 2021
Processing time: 126 Days and 7.1 Hours
Peer-review started: March 17, 2021
First decision: April 4, 2021
Revised: April 16, 2021
Accepted: May 19, 2021
Article in press: May 19, 2021
Published online: July 26, 2021
Processing time: 126 Days and 7.1 Hours
Core Tip
Core Tip: A “null” immunohistochemical staining pattern of mismatch repair (MMR) proteins was revealed, which helped identify this case as sporadic without familial clinical management implications. An in-depth understanding of the abnormal MMR expression is helpful for individualized follow-up treatment and assessment of pro