Ji W, Nie M, Mao JF, Zhang HB, Wang X, Wu XY. Growth hormone cocktail improves hepatopulmonary syndrome secondary to hypopituitarism: A case report. World J Clin Cases 2021; 9(18): 4852-4858 [PMID: 34222458 DOI: 10.12998/wjcc.v9.i18.4852]
Corresponding Author of This Article
Xue-Yan Wu, MD, Professor, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuai Fuyuan, Dong Cheng District, Beijing 100730, China. wsheyan@vip.sina.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jun 26, 2021; 9(18): 4852-4858 Published online Jun 26, 2021. doi: 10.12998/wjcc.v9.i18.4852
Growth hormone cocktail improves hepatopulmonary syndrome secondary to hypopituitarism: A case report
Wen Ji, Min Nie, Jiang-Feng Mao, Hong-Bing Zhang, Xi Wang, Xue-Yan Wu
Wen Ji, Jiang-Feng Mao, Xi Wang, Xue-Yan Wu, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
Min Nie, Department of Endocrinology, Peking Union Medical College Hospital, Beijing 100730, China
Hong-Bing Zhang, Department of Physiology, Collaborative Innovation Center for Cancer Medicine, Institute of Basic Medical Sciences and School of Basic Medicine, Beijing 100005, China
Author contributions: The patient was followed by Ji W under Wu XY’s guidance; Nie M, Mao JF, and Zhang HB reviewed the literature and contributed to manuscript drafting; Wang X analyzed and interpreted the imaging findings; all authors have read and approved the final manuscript.
Supported bythe National Natural Science Foundation of China, No. 81771576 and No. 81971375; and the Beijing Municipal Natural Science Foundation, No. 7202151 and No. 7212080.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflict of interest to report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue-Yan Wu, MD, Professor, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuai Fuyuan, Dong Cheng District, Beijing 100730, China. wsheyan@vip.sina.com
Received: February 8, 2021 Peer-review started: February 8, 2021 First decision: March 29, 2021 Revised: April 2, 2021 Accepted: April 20, 2021 Article in press: April 20, 2021 Published online: June 26, 2021 Processing time: 122 Days and 20.5 Hours
Core Tip
Core Tip: Liver transplantation is currently known to be the only way to cure hepatopulmonary syndrome (HPS). Even after the successful transplantation surgery, metabolic associated fatty liver disease (MAFLD) always recurs in patients with hypopituitarism who do not receive appropriate hormone replacement therapy. We present herein a case of HPS (very severe) induced by panhypopituitarism that was recovered by complete hormone replacement without surgery, especially growth hormone and testosterone. This case report highlights the importance of screening anterior pituitary function in patients with MAFLD or HPS as early as possible. The growth hormone cocktail therapy, especially growth hormone and testosterone, is expected to avoid liver transplantation.
