Case Control Study
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World J Clin Cases. Jun 26, 2021; 9(18): 4553-4558
Published online Jun 26, 2021. doi: 10.12998/wjcc.v9.i18.4553
Significance of highly phosphorylated insulin-like growth factor binding protein-1 and cervical length for prediction of preterm delivery in twin pregnancies
Rui-Hong Lan, Jie Song, Hu-Min Gong, Yang Yang, Hong Yang, Lin-Mei Zheng
Rui-Hong Lan, Jie Song, Hu-Min Gong, Yang Yang, Hong Yang, Lin-Mei Zheng, Department of Obstetrics, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou 570311, Hainan Province, China
Author contributions: Lan RH and Zheng LM the designed this study; Lan RH wrote the manuscript; Lan RH, Song J, Gong HM, Yang Y, Yang H, and Zheng LM contributed to the data collection; All authors proofread the revised manuscript.
Institutional review board statement: The study was approved by the Ethics Committee of Hainan General Hospital.
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: No conflict of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hu-Min Gong, MM, Chief Physician, Department of Obstetrics, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, No. 19 Xiuhua Road, Xiuying District, Haikou 570311, Hainan Province, China. 15595895588@163.com
Received: January 16, 2021
Peer-review started: January 16, 2021
First decision: January 24, 2021
Revised: February 22, 2021
Accepted: March 4, 2021
Article in press: March 4, 2021
Published online: June 26, 2021
Processing time: 145 Days and 22.7 Hours
Core Tip

Core Tip: This study analyzed the efficacy and feasibility of transvaginal ultrasound measurement of cervical length combined with the phosphorylated insulin-like growth factor binding protein-1 (IGFBP-1) test for the prediction of preterm birth in twin pregnancies. The accuracy of the detection was high. In pregnant women with shorter central length, those with positive phosphorylated IGFBP-1 expression had a higher preterm delivery rate than those with negative expression. In pregnant women with longer central length, the effects of phosphorylated IGFBP-1 are weak on preterm delivery.