Opinion Review
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. May 26, 2021; 9(15): 3487-3497
Published online May 26, 2021. doi: 10.12998/wjcc.v9.i15.3487
COVID-19 combined with liver injury: Current challenges and management
Man-Ling Deng, Yong-Jun Chen, Mei-Ling Yang, Yi-Wen Liu, Hui Chen, Xiao-Qing Tang, Xue-Feng Yang
Man-Ling Deng, Yi-Wen Liu, Hui Chen, Xue-Feng Yang, Department of Gastroenterology, The Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, Hengyang 421002, Hunan Province, China
Yong-Jun Chen, Department of Neurology, The Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, Hengyang 421002, Hunan Province, China
Mei-Ling Yang, Department of Oncology, The Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, Hengyang 421002, Hunan Province, China
Xiao-Qing Tang, Institute of Clinical Medicine, The First Affiliated Hospital, Hengyang Medical College, University of South China, Hengyang 421001, Hunan Province, China
Author contributions: Deng ML and Chen YJ equally contributed to this work; Deng ML, Chen YJ, Yang ML, Liu YW, Chen H, Tang XQ, and Yang XF all contributed to the literature review and the writing of this manuscript.
Supported by Novel Coronavirus Pneumonia Emergency Project of University of South China, No. 2020-15 and No. 2020-25; Fund Project of Hengyang City for Prevention and Control of COVID-19, No. 202010031577; and Key Research and Development Program of Hunan Province, No. 2020SK3039 and No. 2020SK3040.
Conflict-of-interest statement: All authors of this article declare that there is no conflict of interest with any person or organization.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xue-Feng Yang, MD, Full Professor, Department of Gastroenterology, The Affiliated Nanhua Hospital, Hengyang Medical College, University of South China, No. 336 Dongfeng Road, Zhuhui District, Hengyang 421002, Hunan Province, China. yxf9988@126.com
Received: January 14, 2021
Peer-review started: January 14, 2021
First decision: February 10, 2021
Revised: March 7, 2021
Accepted: March 29, 2021
Article in press: March 29, 2021
Published online: May 26, 2021
Processing time: 117 Days and 3.7 Hours
Core Tip

Core Tip: The prevention and treatment of coronavirus disease 2019 (COVID-19) combined with liver injury face many challenges. First, the definition of COVID-19 combined with liver injury is not clear, the selected parameters and the time of statistics are inconsistent, and the conclusions about the incidence rate are consistent. Second, the etiology and mechanism of COVID-19 combined liver injury are not clear and need to be studied in depth. Third, there is a lack of effective treatment methods. This article provides and additional view of the incidence of COVID-19-associated liver injury and explores the contemporary management modalities.