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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Apr 6, 2021; 9(10): 2394-2399
Published online Apr 6, 2021. doi: 10.12998/wjcc.v9.i10.2394
Published online Apr 6, 2021. doi: 10.12998/wjcc.v9.i10.2394
Programmed cell death protein-1 inhibitor combined with chimeric antigen receptor T cells in the treatment of relapsed refractory non-Hodgkin lymphoma: A case report
Zhi-Yun Niu, Li Sun, Shu-Peng Wen, Zheng-Rong Song, Lina Xing, Ying Wang, Xue-Jun Zhang, Fu-Xu Wang, Department of Hematology, Second Hospital of Hebei Medical University, Hebei Key Laboratory of Hematology, Shijiazhuang 050000, Hebei Province, China
Jian-Qiang Li, Central Laboratory, Hebei Senlang Biotechnology Co., Shijiazhuang 050000, Hebei Province, China
Author contributions: Wang FX conceptualized and designed the study; Niu ZY, Sun L and Wen SP performed the clinical trial; Xing LN, Li JQ, Song ZR and Wang Yacquired the data; Li JQ prepared the anti-CD19 CAR T-cells; Zhang XJ analyzed and interpreted the data; Niu ZY contributed to the writing and Wang FX revised the manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fu-Xu Wang, PhD, Professor, Department of Hematology, Second Hospital of Hebei Medical University, Hebei Key Laboratory of Hematology, Shijiazhuang 050000, Hebei Province, China. wfxhebmu@163.com
Received: December 15, 2020
Peer-review started: December 15, 2020
First decision: December 28, 2020
Revised: January 6, 2021
Accepted: January 28, 2021
Article in press: January 28, 2021
Published online: April 6, 2021
Processing time: 104 Days and 20.9 Hours
Peer-review started: December 15, 2020
First decision: December 28, 2020
Revised: January 6, 2021
Accepted: January 28, 2021
Article in press: January 28, 2021
Published online: April 6, 2021
Processing time: 104 Days and 20.9 Hours
Core Tip
Core Tip: The mechanism of early loss of chimeric antigen receptor T (CAR-T) cells may be the depletion of activated T cells due to stimulation of the immune checkpoint pathway [such as programmed cell death protein-1 (PD-1)] of lymphoma cells. Immune checkpoints have a critical role in the immune system. This case suggests that PD-1 expression may affect the therapeutic effect of CAR-T cell therapy, and combination CAR-T cells and a PD-1 inhibitor may be a viable treatment option for relapsed and refractory non-Hodgkin lymphoma.