COVID-19 managed with early non-invasive ventilation and a bundle pharmacotherapy: A case report

doi:10.12998/wjcc.v8.i9.1705

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World Journal of Clinical Cases

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Case Report

World J Clin Cases. May 6, 2020; 8(9): 1705-1712
Published online May 6, 2020. doi: 10.12998/wjcc.v8.i9.1705

COVID-19 managed with early non-invasive ventilation and a bundle pharmacotherapy: A case report

Yan-Si Lyu, Xi Meng, Yong-Feng Liu, Bao-Jun Yu, Rong-Lin Chen, Jin-Xiu Li, Xue-Yan Liu, Di Ren, Mian Peng

Mian Peng, Department of Intensive Care Unit, the Third Affiliated Hospital of Shenzhen University, Shenzhen 518001, Guangdong Province, China

Di Ren, Department of Intensive Care Unit, the Second People’s Hospital of Shenzhen, Shenzhen 518001, Guangdong Province, China

Xue-Yan Liu, Department of Intensive Care Unit, Shenzhen People's Hospital, First Affiliated Hospital of Southern University of Science and Technology, the Second Affiliated Hospital of Jinan University, Shenzhen 518020, Guangdong Province, China

Jin-Xiu Li, Xi Meng, Department of Intensive Care Unit, the Third People’s Hospital of Shenzhen, Shenzhen 518001, Guangdong Province, China

Rong-Lin Chen, Yong-Feng Liu, Department of Intensive Care Unit, Shenzhen Longgang Central Hospital, Shenzhen 518001, Guangdong Province, China

Bao-Jun Yu, Department of Intensive Care Unit, Shenzhen Baoan District People’s Hospital, Shenzhen 518001, Guangdong Province, China

Yan-Si Lyu, Department of Dermatology, Shenzhen University General Hospital, Shenzhen 518067, Guangdong Province, China

Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.

Conflict-of-interest statement: The authors declare that they have no conflict of interest.

CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).

Corresponding author: Xue-Yan Liu, PhD, Professor, Department of Intensive Care Unit, Shenzhen People's Hospital, First Affiliated Hospital of Southern University of Science and Technology, the Second Affiliated Hospital of Jinan University, Dongmen North Road No.1017, Luohu District, Shenzhen 518020, Guangdong Province, China. liuxueyan100916@163.com

Received: March 11, 2020
Peer-review started: March 11, 2020
First decision: April 1, 2020
Revised: April 9, 2020
Accepted: April 17, 2020
Article in press: April 17, 2020
Published online: May 6, 2020
Processing time: 50 Days and 0.2 Hours

Core Tip

Core tip: The coronavirus disease 2019 (COVID-19) outbreak has become a public health emergency of international concern. Establishing effective control measures is of urgent importance. We here report a case of severe COVID-19. The patient was treated successfully with early non-invasive ventilation when her arterial oxygen partial pressure/fractional inspired oxygen ratio dropped below 200 mmHg, and a bundle pharmacotherapy which included an antiviral cocktail (lopinavir/ritonavir plus α-interferon), an immunity enhancer (thymosin), a corticosteroid to reduce pulmonary exudation (methylprednisolone), a traditional Chinese medicine-derived anti-inflammatory prescription (Xuebijing), and an anti-coagulant to prevent deep vein thrombosis (heparin). Early non-invasive ventilation with a bundle pharmacotherapy may be an effective regimen for patients with COVID-19.