Ma Q, Wang H, Chen ZN, Wu YQ, Yu DZ, Wang PJ, Shi HB, Su KM. Removal of biofilm is essential for long-term ventilation tube retention. World J Clin Cases 2020; 8(9): 1592-1599 [PMID: 32432137 DOI: 10.12998/wjcc.v8.i9.1592]
Corresponding Author of This Article
Peng-Jun Wang, MD, Doctor, Department of Otorhinolaryngology-Head & Neck Surgery, the Sixth People's Hospital Affiliated to Shanghai Jiaotong University, 600 Yishan Road, Shanghai 200233, China. wangpj@sjtu.edu.cn
Research Domain of This Article
Otorhinolaryngology
Article-Type of This Article
Case Control Study
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Ma Q, Wang H, Chen ZN, Wu YQ, Yu DZ, Wang PJ, Shi HB, Su KM. Removal of biofilm is essential for long-term ventilation tube retention. World J Clin Cases 2020; 8(9): 1592-1599 [PMID: 32432137 DOI: 10.12998/wjcc.v8.i9.1592]
Qiang Ma, Hui Wang, Zheng-Nong Chen, Ya-Qin Wu, Dong-Zhen Yu, Peng-Jun Wang, Hai-Bo Shi, Kai-Ming Su, Department of Otorhinolaryngology–Head & Neck Surgery, the Sixth People’s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China
Hai-Bo Shi, Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai 200233, China
Author contributions: Ma Q wrote the manuscript draft; Wang PJ and Shi HB collected the clinical data; Shi HB designed the study; Wang PJ revised the manuscript; Chen ZN, Wu YQ, and Wang H performed the treatments; Su KM and Yu DZ evaluated the efficacy of the method; all authors read and approved the final manuscript.
Supported byShanghai Leadership Talent Training Plan, No. 2017062; the Key Project of Shanghai Jiao Tong University Medicine Science and Engineering Interdisciplinary Foundation, No. YG2016ZD02; Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support, No. 20152233; Multi-Center Clinical Research Plan of Medical College of Shanghai Jiao Tong University, No. DLY201823; the Clinical Research Plan of Shanghai Shen Kang Hospital Development Center, No. 16CR4022A and No. 16CR3041A; and National Natural Science Foundation of China, No. 81974142.
Institutional review board statement: The study was approved by the Ethics Committee of Shanghai Sixth People’s Hospital (YS-2018-101).
Informed consent statement: All patients gave informed consent.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement, and the manuscript was prepared and revised according to the STROBE Statement.
Corresponding author: Peng-Jun Wang, MD, Doctor, Department of Otorhinolaryngology-Head & Neck Surgery, the Sixth People's Hospital Affiliated to Shanghai Jiaotong University, 600 Yishan Road, Shanghai 200233, China. wangpj@sjtu.edu.cn
Received: December 16, 2019 Peer-review started: December 16, 2019 First decision: February 20, 2020 Revised: March 4, 2020 Accepted: April 15, 2020 Article in press: April 15, 2020 Published online: May 6, 2020 Processing time: 135 Days and 22.3 Hours
Core Tip
Core tip: Long-term ventilation tube retention is necessary in many diseases, such as refractory otitis media with effusion and eustachian tube dysfunction, as well as with the use of Meniett therapy for Ménière disease. However, conventional ventilation tubes are expelled spontaneously within 3 to 12 mo because of tube extrusion or obstruction. Therefore, patients have to undergo two or more myringotomy with ventilation tube placement procedures, along with the risks of anesthesia and surgery, excessive injury to the tympanic membrane and external auditory canal, medical care costs, and impact on school or work. The biofilm plays a crucial role in the development of extrusion or obstruction after myringotomy with ventilation tube placement. It was revealed that, despite the use of short-term tube, biofilm removal has been proven to be a safe and effective treatment for long-term tube retention.
