Li C, Su HB, Liu XY, Hu JH. Clinical characteristics and 28-d outcomes of bacterial infections in patients with hepatitis B virus-related acute-on-chronic liver failure. World J Clin Cases 2020; 8(6): 1042-1055 [PMID: 32258075 DOI: 10.12998/wjcc.v8.i6.1042]
Corresponding Author of This Article
Hai-Bin Su, MD, MPhil, Doctor, Liver Failure Treatment and Research Center, The Fifth Medical Center of Chinese PLA General Hospital, No. 100, West Fourth Ring Road, Beijing 100039, China. suhaibin302@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
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Li C, Su HB, Liu XY, Hu JH. Clinical characteristics and 28-d outcomes of bacterial infections in patients with hepatitis B virus-related acute-on-chronic liver failure. World J Clin Cases 2020; 8(6): 1042-1055 [PMID: 32258075 DOI: 10.12998/wjcc.v8.i6.1042]
World J Clin Cases. Mar 26, 2020; 8(6): 1042-1055 Published online Mar 26, 2020. doi: 10.12998/wjcc.v8.i6.1042
Clinical characteristics and 28-d outcomes of bacterial infections in patients with hepatitis B virus-related acute-on-chronic liver failure
Chen Li, Hai-Bin Su, Xiao-Yan Liu, Jin-Hua Hu
Chen Li, Hai-Bin Su, Xiao-Yan Liu, Jin-Hua Hu, Liver Failure Treatment and Research Center, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
Author contributions: All authors helped to perform the research; Li C, Su HB, and Hu JH designed the study; Li C, Su HB, and Liu XY collected and analyzed the data; Li C wrote the first draft with assistance from Su HB, Hu JH, and Liu XY; Su HB and Hu JH edited the final draft; all authors have read and approved the final manuscript.
Supported byInnovation Projects of The Fifth Medical Center of Chinese PLA General Hospital, No. YNKT2014007.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of The Fifth Medical Center of Chinese PLA General Hospital.
Informed consent statement: Due to the retrospective nature of the study and the anonymous data used, written informed consent could not be obtained from all patients.
Conflict-of-interest statement: All authors declare no conflicts of interest related to this article.
Data sharing statement: No additional data are available.
Corresponding author: Hai-Bin Su, MD, MPhil, Doctor, Liver Failure Treatment and Research Center, The Fifth Medical Center of Chinese PLA General Hospital, No. 100, West Fourth Ring Road, Beijing 100039, China. suhaibin302@163.com
Received: December 10, 2019 Peer-review started: December 10, 2019 First decision: December 30, 2019 Revised: January 7, 2020 Accepted: March 5, 2020 Article in press: March 5, 2020 Published online: March 26, 2020 Processing time: 106 Days and 18.6 Hours
Core Tip
Core tip: Bacterial infections (BIs) play pivotal roles in the deterioration of clinical course in patients with acute-on-chronic liver failure (ACLF). This study aimed to investigate the clinical characteristics of first BIs in patients with hepatitis B virus-ACLF, as defined by the Chinese Group on the Study of Severe Hepatitis B. Healthcare-associated and nosocomial BIs were the most common types. Pneumonia was the most common form of BI. Gram-negative bacteria accounted for 83.6%, and multidrug-resistant organisms accounted for 29.5% of bacteria detected. The 28-d transplant-free survival rates of the patients were very low. Chinese Group on the Study of Severe Hepatitis B-ACLF score, acute kidney injury, bloodstream infection, prothrombin activity, and invasive catheterization were the independent predictors of 28-d outcomes.
