Komeda Y, Sakurai T, Sakai K, Morita Y, Hashimoto A, Nagai T, Hagiwara S, Matsumura I, Nishio K, Kudo M. Refractory case of ulcerative colitis with idiopathic thrombocytopenic purpura successfully treated by Janus kinase inhibitor tofacitinib: A case report. World J Clin Cases 2020; 8(24): 6389-6395 [PMID: 33392322 DOI: 10.12998/wjcc.v8.i24.6389]
Corresponding Author of This Article
Toshiharu Sakurai, MD, PhD, Assistant Professor, Senior Lecturer, Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka 589-8511, Japan. sakurai@med.kindai.ac.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Report
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Komeda Y, Sakurai T, Sakai K, Morita Y, Hashimoto A, Nagai T, Hagiwara S, Matsumura I, Nishio K, Kudo M. Refractory case of ulcerative colitis with idiopathic thrombocytopenic purpura successfully treated by Janus kinase inhibitor tofacitinib: A case report. World J Clin Cases 2020; 8(24): 6389-6395 [PMID: 33392322 DOI: 10.12998/wjcc.v8.i24.6389]
World J Clin Cases. Dec 26, 2020; 8(24): 6389-6395 Published online Dec 26, 2020. doi: 10.12998/wjcc.v8.i24.6389
Refractory case of ulcerative colitis with idiopathic thrombocytopenic purpura successfully treated by Janus kinase inhibitor tofacitinib: A case report
Yoriaki Komeda, Toshiharu Sakurai, Arito Hashimoto, Tomoyuki Nagai, Satoru Hagiwara, Masatoshi Kudo, Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka 589-8511, Japan
Kazuko Sakai, Kazuto Nishio, Department of Genome Biology, Kindai University Faculty of Medicine, Osaka 589-8511, Japan
Yasuyoshi Morita, Itaru Matsumura, Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Osaka 589-8511, Japan
Author contributions: Komeda K and Sakurai T wrote the manuscript. Komeda K, Sakurai T, Morita Y and Hashimoto A was the patient’s doctor in charge and was responsible for collecting medical history. Komeda Y, Sakurai T, Sakai K, Nagai T, Hagiwara S, Matsumura I, Nishio K and Kudo M contributed data analysis and interpretation of data.
Supported byJSPS KAKENHI, No. 17K09396, No. 17H06404, and No. 20K08368.
Informed consent statement: Written informed consent was obtained from the patient for publication of this report and any accompanying images. The study was approved by the relevant institutional review boards (#28-224).
Conflict-of-interest statement: The authors declare no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Toshiharu Sakurai, MD, PhD, Assistant Professor, Senior Lecturer, Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka 589-8511, Japan. sakurai@med.kindai.ac.jp
Received: July 27, 2020 Peer-review started: July 27, 2020 First decision: August 8, 2020 Revised: October 29, 2020 Accepted: November 4, 2020 Article in press: November 4, 2020 Published online: December 26, 2020 Processing time: 145 Days and 2.9 Hours
Core Tip
Core Tip: We herein report a refractory case of ulcerative colitis associated with idiopathic thrombocytopenic purpura successfully treated with tofacitinib. The relationship between these two disease entities underscore treatment implications, given their potentially shared immunological pathway and responses to similar medications. To investigate changes in gene signatures during tofacitinib therapy, whole transcriptomic sequencing was performed for inflamed rectal mucosae obtained before and after the initiation of Janus kinase (JAK) inhibitor. Distinct molecular signatures seemed to be regulated by JAK inhibition and tumor necrosis factor blockade, suggesting that the identification of gene sets may be able to predict therapeutic responses to medications.
