Case Report
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Oct 26, 2020; 8(20): 4958-4965
Published online Oct 26, 2020. doi: 10.12998/wjcc.v8.i20.4958
Amiodarone-induced hepatotoxicity — quantitative measurement of iodine density in the liver using dual-energy computed tomography: Three case reports
Hai-Juan Lv, Hong-Wei Zhao
Hai-Juan Lv, Hong-Wei Zhao, Department of Radiology, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang Province, China
Author contributions: Lv HJ performed the literature search and drafted the manuscript; Zhao HW designed the study and reviewed the final manuscript; all authors have read and approved the final manuscript.
Supported by Science and Technology Bureau of Jiaxing, Zhejiang Province of China, No. 2017BY18018.
Informed consent statement: This study was approved by the Ethics Committee of the Second Affiliated Hospital of Jiaxing University. The three patients gave written informed consent prior to the computed tomography examination.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hong-Wei Zhao, MD, Chief Doctor, Department of Radiology, The Second Affiliated Hospital of Jiaxing University, No.1518 Huancheng North Road, Jiaxing 314000, Zhejiang Province, China. zhw0314@hotmail.com
Received: March 31, 2020
Peer-review started: March 31, 2020
First decision: August 23, 2020
Revised: August 29, 2020
Accepted: September 10, 2020
Article in press: September 10, 2020
Published online: October 26, 2020
Processing time: 208 Days and 21.5 Hours
Core Tip

Core Tip: Amiodarone is the drug most commonly used to manage arrhythmias. Long-term amiodarone administration causes hepatotoxicity due to iodine accumulation in the liver. Our study investigated three patients receiving low-dose oral amiodarone therapy for the long-term prevention of paroxysmal atrial fibrillation in whom quantitative measurement of the iodine concentration in the liver was measured using dual-energy computed tomography. Dual-energy computed tomography is a potentially noninvasive diagnostic tool for quantifying iodine concentration in the liver and monitoring adverse reactions due to amiodarone.