Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Sep 6, 2020; 8(17): 3697-3707
Published online Sep 6, 2020. doi: 10.12998/wjcc.v8.i17.3697
Somatostatin receptor scintigraphy in the follow up of neuroendocrine neoplasms of appendix
Jelena Saponjski, Djuro Macut, Dragana Sobic-Saranovic, Sanja Ognjanovic, Ivana Bozic Antic, Djordje Pavlovic, Vera Artiko
Jelena Saponjski, Center for Nuclear Medicine, Clinical Center of Serbia, Belgrade 11000, Serbia
Djuro Macut, Sanja Ognjanovic, Ivana Bozic Antic, Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade 11000, Serbia
Dragana Sobic-Saranovic, Vera Artiko, Center for Nuclear Medicine Clinical Center of Serbia, Faculty of Medicine University of Belgrade, Belgrade 11000, Serbia
Djordje Pavlovic, University Children's Clinic, Belgrade 11000, Serbia
Author contributions: Saponjski J designed and performed research and wrote the paper; Macut Dj, Sobic Saranovic D and Artiko V designed the research and supervised the report; Ognjanovic S, Bozic Antic I and Pavlovic Dj provided clinical advice and contributed to analysis.
Supported by Ministry of Science, Education and Technology Republic of Serbia, No. 175018.
Institutional review board statement: The study was reviewed and approved by the Ethic Committee of the Faculty of Medicine University of Belgrade No. 1550/V-9 from 31.05.2019.
Informed consent statement: Before each investigation individual patient gave written consent that anonymous data and the results of investigation can be used for clinical, educational and scientific purposes (with the agreement of Ethical Committee Clinical Center of Serbia, Faculty of Medicine University of Belgrade No. 668/6 from 19.04.2018).
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Vera Artiko, PhD, Professor, Center for Nuclear Medicine Clinical Center of Serbia, Faculty of Medicine University of Belgrade, Visegradska 26, Belgrade 11000, Serbia. vera.artiko@gmail.com
Received: May 1, 2020
Peer-review started: May 1, 2020
First decision: June 13, 2020
Revised: June 24, 2020
Accepted: August 13, 2020
Article in press: August 13, 2020
Published online: September 6, 2020
Processing time: 125 Days and 22.3 Hours
Core Tip

Core tip: The aim is to establish the role of somatostatin receptor scintigraphy (SRS) in the management of 35 patients with neuroendocrine tumors of appendix. Sensitivity of the method was 92.31%, negative predictive value was 95.00% and accuracy 88.57%. In 8 patients SRS significantly changed the management. Median progression-free survival in SRS positive patients was 52 months while in SRS negative patients it was 60 months, without statistically significant difference between the two groups (P = 0.434). Our results confirmed the value of SRS in the follow-up of the patients with neuroendocrine tumors of appendix after surgery, if recurrences or metastases are suspected.