Lei L, Wang MJ, Zhang S, Hu DJ. Effects of prostaglandin E combined with continuous renal replacement therapy on septic acute kidney injury. World J Clin Cases 2020; 8(13): 2738-2748 [PMID: 32742984 DOI: 10.12998/wjcc.v8.i13.2738]
Corresponding Author of This Article
Da-Jun Hu, BSc, Attending Doctor, Department of Nephrology, the Second People's Hospital of Three Gorges University (Yichang Second People's Hospital), No. 21, Xiling 1 Road, Yichang 443000, Hubei Province, China. hudiba2872@163.com
Research Domain of This Article
Urology & Nephrology
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Jul 6, 2020; 8(13): 2738-2748 Published online Jul 6, 2020. doi: 10.12998/wjcc.v8.i13.2738
Effects of prostaglandin E combined with continuous renal replacement therapy on septic acute kidney injury
Li Lei, Ming-Jun Wang, Sheng Zhang, Da-Jun Hu
Li Lei, Ming-Jun Wang, Sheng Zhang, Da-Jun Hu, Department of Nephrology, the Second People's Hospital of Three Gorges University (Yichang Second People's Hospital), Yichang 443000, Hubei Province, China
Li Lei, Ming-Jun Wang, Sheng Zhang, Da-Jun Hu, Institute of Nephrology of Integrated Chinese and Western Medicine of Three Gorges University, Yichang 443000, Hubei Province, China
Author contributions: Lei L and Wang MJ contributed equally to this study; Hu DJ wrote the first draft of the manuscript; Lei L, Wang MJ, and Zhang S performed the material preparation and data collection and analysis; all authors contributed to the study conception and design, commented on previous versions of the manuscript, and read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Yichang Second People's Hospital.
Informed consent statement: All participates provided written informed consent prior to study inclusion.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Da-Jun Hu, BSc, Attending Doctor, Department of Nephrology, the Second People's Hospital of Three Gorges University (Yichang Second People's Hospital), No. 21, Xiling 1 Road, Yichang 443000, Hubei Province, China. hudiba2872@163.com
Received: February 27, 2020 Peer-review started: February 27, 2020 First decision: April 21, 2020 Revised: May 25, 2020 Accepted: June 9, 2020 Article in press: June 9, 2020 Published online: July 6, 2020 Processing time: 131 Days and 0.1 Hours
Core Tip
Core tip: Prostaglandin E combined with continuous renal replacement therapy is clinically effective for treating septic acute kidney injury, and the combination therapy can significantly improve renal function and reduce inflammatory responses. However, there are still unsolved problems in this study. For instance, the patient survival has been observed for 28 d, and causes of patient death are various, but no detailed analysis has been made on changes in the survival rate to improve the selection accuracy of therapeutic schemes. In addition, more reference directions for adverse reactions can be provided to improve the safety of drugs. These deficiencies will be our further research direction, so as to provide effective measures for the early treatment of patients with septic acute kidney injury.
