©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Nov 6, 2019; 7(21): 3622-3631
Published online Nov 6, 2019. doi: 10.12998/wjcc.v7.i21.3622
Published online Nov 6, 2019. doi: 10.12998/wjcc.v7.i21.3622
Child with Wiskott–Aldrich syndrome underwent atypical immune reconstruction after umbilical cord blood transplantation: A case report
Bo-Han Li, Shao-Yan Hu, Department of Hematology and Oncology, Children’s Hospital of Soochow University, Suzhou 215000, Jiangsu Province, China
Author contributions: Li BH and Hu SY wrote and edited the final manuscript; both authors have read and approved the final manuscript.
Supported by National Natural Science Foundation of China , No. 81770193 .
Informed consent statement: Written informed consent was obtained from the patient’s legal guardian(s) for publication of this case report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest in relation to this manuscript.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Shao-Yan Hu, PhD, Chief Doctor, Department of Hematology and Oncology, Children’s Hospital of Soochow University, 92 Zhongnan Street, Suzhou 215000, Jiangsu Province, China. hsy139@126.com
Telephone: +86-512-80692929
Received: April 17, 2019
Peer-review started: April 18, 2019
First decision: June 12, 2019
Revised: June 21, 2019
Accepted: July 20, 2019
Article in press: July 20, 2019
Published online: November 6, 2019
Processing time: 206 Days and 0.2 Hours
Peer-review started: April 18, 2019
First decision: June 12, 2019
Revised: June 21, 2019
Accepted: July 20, 2019
Article in press: July 20, 2019
Published online: November 6, 2019
Processing time: 206 Days and 0.2 Hours
Core Tip
Core tip: The timely reconstitution of a donor-derived immune system is of utmost importance for the recovery and long-term survival of patients after hematopoietic stem cell transplantation. Here, we describe a case of Wiskott–Aldrich syndrome treated by umbilical cord blood transplantation with the atypical process of immune reconstitution. Our case revealed that an increase in the number of lymphocytes (especially T cells) earlier than granulocytes may be a marker of a good prognosis in patients. This experience will guide clinical scientists, especially hematologists, to deal with similar situations and encourage them to identify more processes that require immune reconstruction.