Efficient management of secondary haemophagocytic lymphohistiocytosis with intravenous steroids and γ-immunoglobulin infusions
Sarah Georgiadou, Nikolaos K Gatselis, Aggelos Stefos, Kalliopi Zachou, Konstantinos Makaritsis, Eirini I Rigopoulou, George N Dalekos
Sarah Georgiadou, Nikolaos K Gatselis, Aggelos Stefos, Kalliopi Zachou, Konstantinos Makaritsis, Eirini I Rigopoulou, George N Dalekos, Department of Medicine and Research Laboratory of Internal Medicine, University Hospital of Larissa, Larissa 41110, Greece
Nikolaos K Gatselis, Kalliopi Zachou, Konstantinos Makaritsis, Eirini I Rigopoulou, George N Dalekos, Institute of Internal Medicine and Hepatology, University Hospital of Larissa, Larissa 41447, Greece
Author contributions: Makaritsis K, Rigopoulou EI, Dalekos GN made the conception and designed of the work, treated the patients, analyzed and interpreted of the data, critical revision of the manuscript and final approved of the version to be published; Georgiadou S, Gatselis NK, Stefos A, Zachou K treated the patients, made the collection, statistical analysis and interpretation of the data, wrote the first draft of the manuscript and final approved of the version to be published.
Institutional review board statement: The ethical committee of the University Hospital of Larissa approved the protocol which conforms to the ethical guidelines of the 1975 Declaration of Helsinki as reflected in a priori approval by the institution's human research committee.
Informed consent statement: Patients were not required to give informed consent to the study because the retrospective analysis used anonymous clinical data that were obtained after each patient agreed to the treatment schedule by written consent.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: George N Dalekos, MD, PhD, Chairman, Full Professor, Department of Medicine and Research Laboratory of Internal Medicine, University Hospital of Larissa, Mezourlo, Larissa 41110, Greece.
dalekos@med.uth.gr
Telephone: +30-241-3502285 Fax: +30-241-3501557
Received: June 5, 2019
Peer-review started: June 6, 2019
First decision: September 9, 2019
Revised: September 20, 2019
Accepted: October 15, 2019
Article in press: October 15, 2019
Published online: November 6, 2019
Processing time: 156 Days and 18.5 Hours
