©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Aug 26, 2019; 7(16): 2134-2142
Published online Aug 26, 2019. doi: 10.12998/wjcc.v7.i16.2134
Published online Aug 26, 2019. doi: 10.12998/wjcc.v7.i16.2134
Role of infrapatellar fat pad in pathological process of knee osteoarthritis: Future applications in treatment
Li-Feng Jiang, Jing-Hua Fang, Li-Dong Wu, Department of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, Zhejiang Province, China
Author contributions: Jiang LF and Fang JH contributed equally to this work and should be considered as co-first authors. All authors have read and approved the final submitted manuscript.
Conflict-of-interest statement: There are no conflicts of interest declared by any other author.
Corresponding author: Li-Dong Wu, MPhil, Chief Doctor, Chief Doctor, Department of Orthopedics Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88, Jiefang Road, Hangzhou 310000, Zhejiang Province, China. wulidong@zju.edu.cn
Telephone: +86-571-87783550 Fax: +86-0571-87783550
Received: January 19, 2019
Peer-review started: January 22, 2019
First decision: May 31, 2019
Revised: June 11, 2019
Accepted: June 26, 2019
Article in press: June 27, 2019
Published online: August 26, 2019
Processing time: 219 Days and 22.7 Hours
Peer-review started: January 22, 2019
First decision: May 31, 2019
Revised: June 11, 2019
Accepted: June 26, 2019
Article in press: June 27, 2019
Published online: August 26, 2019
Processing time: 219 Days and 22.7 Hours
Core Tip
Core tip: The infrapatellar fat pad (IPFP) is a piece of adipose tissue, however, due to its special position in the knee joint and the anatomical and physiological characteristics, IPFP plays important roles in the pathological process of osteoarthritis (OA). Meanwhile, the IPFP is becoming a kind of important, minimally invasive fat stem cell source, which can treat OA. We herein widely review the pertinent literature, summarize and analyze the IPFP related vascular and nerve supply, the dual role of IPFP, and its future application prospects.