Yuan JL, Wang WX, Hu WL. Clinical features of syphilitic myelitis with longitudinally extensive myelopathy on spinal magnetic resonance imaging. World J Clin Cases 2019; 7(11): 1282-1290 [PMID: 31236392 DOI: 10.12998/wjcc.v7.i11.1282]
Corresponding Author of This Article
Wen-Li Hu, MD, Director, Doctor, Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, 8 Gongti South, Chaoyang District, Beijing 100020, China. wenlihu3366@126.com
Research Domain of This Article
Clinical Neurology
Article-Type of This Article
Observational Study
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Yuan JL, Wang WX, Hu WL. Clinical features of syphilitic myelitis with longitudinally extensive myelopathy on spinal magnetic resonance imaging. World J Clin Cases 2019; 7(11): 1282-1290 [PMID: 31236392 DOI: 10.12998/wjcc.v7.i11.1282]
World J Clin Cases. Jun 6, 2019; 7(11): 1282-1290 Published online Jun 6, 2019. doi: 10.12998/wjcc.v7.i11.1282
Clinical features of syphilitic myelitis with longitudinally extensive myelopathy on spinal magnetic resonance imaging
Jun-Liang Yuan, Wei-Xue Wang, Wen-Li Hu
Jun-Liang Yuan, Wen-Li Hu, Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
Wei-Xue Wang, Department of Oncology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
Author contributions: Yuan JL and Wang WX are co-first authors; Yuan JL, Wang WX, and Hu WL designed and performed the research; Yuan JL and Wang WX collected and analyzed the data; Yuan JL and Wang WX wrote the paper.
Supported bythe National Natural Science Foundation of China, No. 81301016; and the Beijing Municipal Administration of Hospitals Incubating Program, No. PX2019009.
Institutional review board statement: Our work was approved by the Ethics Committee of Beijing Chaoyang Hospital, Capital Medical University.
Informed consent statement: The patient gave informed consent.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement–checklist of items, and the manuscript was prepared and revised according to the STROBE Statement–checklist of items.
Corresponding author: Wen-Li Hu, MD, Director, Doctor, Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, 8 Gongti South, Chaoyang District, Beijing 100020, China. wenlihu3366@126.com
Telephone: +86-10-85231376 Fax: +86-10-85231376
Received: January 23, 2019 Peer-review started: January 23, 2019 First decision: March 14, 2019 Revised: April 16, 2019 Accepted: May 2, 2019 Article in press: May 2, 2019 Published online: June 6, 2019 Processing time: 135 Days and 14.7 Hours
Core Tip
Core tip: Syphilitic myelitis is a very rare manifestation of neurosyphilis. Early diagnosis and treatment are crucial because it represents a treatable and potentially reversible cause of myelopathy if treated with penicillin. Herein, we report a 25-year-old young man presenting with symptoms of sensory disturbance, due to syphilitic myelitis with longitudinally extensive myelopathy with "flip-flop sign" on spinal magnetic resonance imaging. Furthermore, we summarized the clinical features of syphilitic myelitis with longitudinally extensive myelopathy by reviewing the relevant literature. Our study also raises awareness of an important complication of neurosyphilis due to homosexuality. Attention is drawn upon the importance of doing serological tests for syphilis when any atypical neurological disorders are presented.
