Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 6, 2019; 7(11): 1262-1269
Published online Jun 6, 2019. doi: 10.12998/wjcc.v7.i11.1262
Published online Jun 6, 2019. doi: 10.12998/wjcc.v7.i11.1262
Elevated levels of interleukin-1β, interleukin-6, tumor necrosis factor-α and vascular endothelial growth factor in patients with knee articular cartilage injury
Zhen-Wei Wang, Le Chen, Xiao-Rui Hao, Zhen-An Qu, Shi-Bo Huang, Xiao-Jun Ma, Jian-Chuan Wang, Wei-Ming Wang, Department of Sports Medicine, Affiliated Zhongshan Hospital of Dalian University, Dalian 16000, Liaoning Province, China
Author contributions: Wang ZW performed the majority of experiments and analyzed the data; Chen L, Hao XR, Ou ZA, Huang SB, Ma XJ and Wang JC performed the experiments; Wang WM designed the research and wrote the paper.
Institutional review board statement: This study has been approved by the ethnic committee of Affiliated Zhongshan Hospital of Dalian University.
Conflict-of-interest statement: All authors have no conflict-of-interest to state.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Wei-Ming Wang, BSc, MD, PhD, Professor, Department of Sports Medicine, Affiliated Zhongshan Hospital of Dalian University, 6 Jiefang Jie, Zhongshan District, Dalian 116001, Liaoning Province, China. wangwm_01@126.com
Telephone: +86-411-62893145 Fax: +86-411-62893145
Received: February 22, 2019
Peer-review started: February 24, 2019
First decision: March 10, 2019
Revised: March 20, 2019
Accepted: April 8, 2019
Article in press: April 9, 2019
Published online: June 6, 2019
Processing time: 105 Days and 13.2 Hours
Peer-review started: February 24, 2019
First decision: March 10, 2019
Revised: March 20, 2019
Accepted: April 8, 2019
Article in press: April 9, 2019
Published online: June 6, 2019
Processing time: 105 Days and 13.2 Hours
Core Tip
Core tip: Increased levels of interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α and vascular endothelial growth factor are found in patients with knee articular cartilage injury, and are associated with the disease severity, suggesting that they might be involved in the pathogenesis of knee articular cartilage injury. Furthermore, therapeutically targeting them might be beneficial for the treatment of knee articular cartilage injury.