Copyright
©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Clin Cases. Jun 6, 2019; 7(11): 1253-1261
Published online Jun 6, 2019. doi: 10.12998/wjcc.v7.i11.1253
Published online Jun 6, 2019. doi: 10.12998/wjcc.v7.i11.1253
Antibiotics and immunotherapy in gastrointestinal tumors: Friend or foe?
Cong Yan, Xiao-Xuan Tu, Wei Wu, Zhou Tong, Lu-Lu Liu, Yi Zheng, Wei-Qin Jiang, Peng Zhao, Wei-Jia Fang, Hang-Yu Zhang, Department of Medical Oncology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, Zhejiang Province, China
Author contributions: Yan C performed the majority of the writing and prepared the tables; Zhang HY designed the outline and coordinated the writing of the paper; other coauthors provided the input in writing the paper.
Supported by the Major Scientific Project of Zhejiang , No. 2017C03028 .
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors who contributed their efforts in this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Hang-Yu Zhang, MD, Attending Doctor, Department of Medical Oncology, First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79, Qingchun Road, Hangzhou 310000, Zhejiang Province, China. zhanghangyu@zju.edu.cn
Telephone: +86-15757747033 Fax: +86-571-87236858
Received: March 15, 2019
Peer-review started: March 15, 2019
First decision: March 29, 2019
Revised: April 7, 2019
Accepted: April 18, 2019
Article in press: April 19, 2019
Published online: June 6, 2019
Processing time: 84 Days and 5.2 Hours
Peer-review started: March 15, 2019
First decision: March 29, 2019
Revised: April 7, 2019
Accepted: April 18, 2019
Article in press: April 19, 2019
Published online: June 6, 2019
Processing time: 84 Days and 5.2 Hours
Core Tip
Core tip: With the widespread use of immunotherapy for almost all types of cancers and the extensive usage of antibiotics in many countries, the association between antibiotics and immunotherapy deserves an investigation based on some studies which showed that the gut microbiota plays an important role in immunotherapy. We reviewed the relevant papers and found that antibiotics may attenuate the effect of immunotherapy.