Cho JH, Goo EJ, Kim KO, Lee SH, Jang BI, Kim TN. Efficacy of 0.5-L vs 1-L polyethylene glycol containing ascorbic acid as additional colon cleansing methods for inadequate bowel preparation as expected by last stool examination before colonoscopy. World J Clin Cases 2019; 7(1): 39-48 [PMID: 30637251 DOI: 10.12998/wjcc.v7.i1.39]
Corresponding Author of This Article
Tae Nyeun Kim, MD, PhD, Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yeungnam University College of Medicine, 170 Hyeonchung-ro, Nam-gu, Daegu 42415, South Korea. tnkim@yu.ac.kr
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Medicine, Research & Experimental
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Clinical Trials Study
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Cho JH, Goo EJ, Kim KO, Lee SH, Jang BI, Kim TN. Efficacy of 0.5-L vs 1-L polyethylene glycol containing ascorbic acid as additional colon cleansing methods for inadequate bowel preparation as expected by last stool examination before colonoscopy. World J Clin Cases 2019; 7(1): 39-48 [PMID: 30637251 DOI: 10.12998/wjcc.v7.i1.39]
World J Clin Cases. Jan 6, 2019; 7(1): 39-48 Published online Jan 6, 2019. doi: 10.12998/wjcc.v7.i1.39
Efficacy of 0.5-L vs 1-L polyethylene glycol containing ascorbic acid as additional colon cleansing methods for inadequate bowel preparation as expected by last stool examination before colonoscopy
Joon Hyun Cho, Eun Joo Goo, Kyeong Ok Kim, Si Hyung Lee, Byung Ik Jang, Tae Nyeun Kim
Joon Hyun Cho, Eun Joo Goo, Kyeong Ok Kim, Si Hyung Lee, Byung Ik Jang, Tae Nyeun Kim, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu 42415, South Korea
Author contributions: Kim TN and Kim KO designed the research; Kim TN, Jang BI, Lee SH, Kim KO, and Goo EJ performed the research; Goo EJ and Cho JH analyzed the data; Kim TN and Cho JH wrote the paper; Kim TN and Cho JH revised the manuscript.
Institutional review board statement: The study was performed in accordance with the Helsinki Declaration and the protocol and informed consent form used were approved beforehand by the Institutional Review Board of Yeungnam University Hospital (IRB No. 2016-03-019).
Informed consent statement: All patients provided written informed consent.
Conflict-of-interest statement: The authors declare no conflicts of interest regarding this manuscript.
Data sharing statement: There are no additional data available for this study.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Corresponding author: Tae Nyeun Kim, MD, PhD, Professor, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yeungnam University College of Medicine, 170 Hyeonchung-ro, Nam-gu, Daegu 42415, South Korea. tnkim@yu.ac.kr
Telephone: +82-53-6203842 Fax: +82-53-6548386
Received: September 21, 2018 Peer-review started: September 21, 2018 First decision: November 2, 2018 Revised: November 19, 2018 Accepted: November 23, 2018 Article in press: November 24, 2018 Published online: January 6, 2019 Processing time: 105 Days and 22.9 Hours
Core Tip
Core tip: The most reasonable rescue option in patients with inadequate bowel preparation is early suspicion and identification of patients with inadequate preparation before sedation, additional oral ingestion of a suitable preparation, and same-day colonoscopy. This is the first prospective randomized clinical trial to compare the effects of two additional polyethylene glycol (PEG) containing ascorbic acid (PEG + Asc) doses. The study shows that the bowel cleansing efficacy of an additional 0.5-L PEG + Asc was not inferior to that of an additional 1-L PEG + Asc when administered prior to colonoscopy in patients with suspected inadequate bowel preparation. Thus, the additional 0.5-L PEG + Asc regimen appears to be sufficient when inadequate bowel preparation is expected before initiating colonoscopy, based on considerations of bowel cleansing efficacy and patient satisfaction.
